| CDKL2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CDKL2, KKIAMRE, P56, cyclin dependent kinase like 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603442; MGI: 1858227; HomoloGene: 55793; GeneCards: CDKL2; OMA:CDKL2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.[5][6]
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.[6]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000138769 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029403 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–2574. PMID 9000130.
- ^ a b "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".
Further reading
[edit]- Marracci GH, Marquardt WE, Strehlow A, McKeon GP, Gross J, Buck DC, et al. (Jun 2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochemical and Biophysical Research Communications. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
- Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC (Nov 2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nature Structural & Molecular Biology. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID 15502848. S2CID 6869429.
- Tao J, Esch H, Hagedorn-Greiwe M, Hoffmann K, Moser B, Raynaud M, et al. (Dec 2004). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation". American Journal of Human Genetics. 75 (6): 1149–1154. doi:10.1086/426460. PMC 1182152. PMID 15499549.
- Sanger Center, Genome Sequencing Center (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC (Apr 1995). "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors". Journal of Biological Chemistry. 270 (16): 9115–9120. doi:10.1074/jbc.270.16.9115. PMID 7721825.
External links
[edit]- Human CDKL2 genome location and CDKL2 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q92772 (Cyclin-dependent kinase-like 2) at the PDBe-KB.
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