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Comment: In accordance with Wikipedia's Conflict of interest guideline, I disclose that I have a conflict of interest regarding the subject of this article. Suandjames (talk) 15:32, 28 September 2026 (UTC)
Soo-Kyung Lee is a South Korean-American neuroscientist and professor whose research focuses on neural development, gene regulation, and neurodevelopmental disorders. She is an Empire Innovation Professor and the Om P. Bahl Endowed Professor in the Department of Biological Sciences at the University at Buffalo, where she serves as director of the FOXG1 Research Center. She is also chief scientific officer of the FOXG1 Research Foundation.
Lee's research has investigated the transcriptional and epigenetic mechanisms that control the development and specification of neuronal and glial cell types in the central nervous system. Her more recent work has focused on FOXG1 syndrome, a rare neurodevelopmental disorder caused by pathogenic variants in the FOXG1 gene, and on developing therapeutic approaches for the disorder.
Education and career
[edit]Lee received her Ph.D. from Chonnam National University in South Korea. She subsequently conducted research at the Salk Institute for Biological Studies.
Lee held a faculty position at Baylor College of Medicine in Houston, Texas, and later joined Oregon Health & Science University (OHSU), where she was a professor of pediatrics and conducted research on the genetic programs governing development of the central nervous system.
In 2019, Lee joined the University at Buffalo. She holds the titles of SUNY Empire Innovation Professor and Om P. Bahl Endowed Professor in the Department of Biological Sciences.
In 2024, the University at Buffalo established the FOXG1 Research Center, with Lee as its inaugural director. The center was created to study the biology of FOXG1 syndrome and to translate basic research findings toward therapeutic development.[1]
Research
[edit]Neural development and gene regulation
[edit]Lee's research has examined the molecular mechanisms that generate cellular diversity in the developing central nervous system. Her work has focused particularly on transcription factors and epigenetic regulators that determine neuronal cell identity and the formation of neural circuits.
Her laboratory has studied the development of neuronal subtypes in the spinal cord, forebrain and other regions of the central nervous system. This research has included studies of transcriptional networks controlling motor neurons and interneurons, as well as mechanisms regulating the development of neurons and glial cells.
FOXG1 and FOXG1 syndrome
[edit]A major focus of Lee's research is the transcription factor FOXG1 and FOXG1 syndrome. FOXG1 has an important role in development of the forebrain, and pathogenic variants affecting the gene can cause severe neurodevelopmental abnormalities.
Lee and her collaborators have developed experimental models of FOXG1 syndrome, including patient-specific mouse models and human cell-based systems, to investigate how different FOXG1 mutations alter brain development and function.[2]
In 2025, Lee and colleagues reported a patient-specific mouse model carrying a FOXG1 frameshift mutation in Nature Communications. The study examined cellular and molecular abnormalities associated with FOXG1 deficiency and used the model to investigate the pathophysiology of FOXG1 syndrome.[3]
Lee's research program has also investigated therapeutic strategies for FOXG1 syndrome, including gene-based approaches. The University at Buffalo reported in 2026 that a FOXG1 therapy developed by Lee and collaborators had received clearance from the U.S. Food and Drug Administration to enter clinical trials and that clinical studies began in April 2026.[4]
FOXG1 Research Center
[edit]Lee is the founding director of the FOXG1 Research Center at the University at Buffalo. Announced in 2024, the center brings together researchers studying FOXG1 biology, neurodevelopment and therapeutic development. Its research program is intended to connect basic studies of brain development with preclinical and clinical development of treatments for FOXG1 syndrome.[5]
Lee also serves as chief scientific officer of the FOXG1 Research Foundation, a patient-led nonprofit organization that supports research and therapeutic development for FOXG1 syndrome.[6]
Personal connection to FOXG1 syndrome
[edit]Lee's research on FOXG1 syndrome also has a personal connection. Her daughter, Yuna, was diagnosed with FOXG1 syndrome at age two. Lee and her husband, biologist Jae W. Lee, subsequently expanded their research efforts on FOXG1 and the biological mechanisms underlying the disorder.[7]
Their work on FOXG1 syndrome has included studies of disease mechanisms, patient-specific models and potential therapeutic approaches. Lee has described her daughter's diagnosis as a major influence on the direction of her research toward translational studies of FOXG1 syndrome.
Selected research
[edit]Lee's published research includes studies of transcriptional and epigenetic regulation of neural development, neuronal subtype specification, FOXG1-dependent forebrain development and the molecular mechanisms of FOXG1 syndrome.
Her work has appeared in journals including Neuron, Developmental Cell, Nature Communications, Cell Reports and PLOS Genetics.
References
[edit]- ^ "Soo-Kyung Lee". www.buffalo.edu. Retrieved 2026-09-28.
- ^ Jeon, Shin; Park, Jaein; Moon, Ji Hwan; Shin, Dongjun; Li, Liwen; O’Shea, Holly; Hwang, Seon-Ung; Lee, Hyo-Jong; Brimble, Elise; Lee, Jae W.; Clark, Stewart D.; Lee, Soo-Kyung (2025-05-22). "The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome". Nature Communications. 16 (1). Nature Publishing Group: 4760. Bibcode:2025NatCo..16.4760J. doi:10.1038/s41467-025-59838-4. ISSN 2041-1723. PMC 12099012. PMID 40404610.
- ^ Jeon, Shin; Park, Jaein; Moon, Ji Hwan; Shin, Dongjun; Li, Liwen; O’Shea, Holly; Hwang, Seon-Ung; Lee, Hyo-Jong; Brimble, Elise; Lee, Jae W.; Clark, Stewart D.; Lee, Soo-Kyung (2025-05-22). "The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome". Nature Communications. 16 (1). Nature Publishing Group: 4760. Bibcode:2025NatCo..16.4760J. doi:10.1038/s41467-025-59838-4. ISSN 2041-1723. PMC 12099012. PMID 40404610.
- ^ "Media Advisory: UB symposium to spotlight researcher behind FOXG1 drug undergoing clinical trials". www.buffalo.edu. Retrieved 2026-09-28.
- ^ "UB launches center to find treatments for FOXG1 syndrome". www.buffalo.edu. Retrieved 2026-09-28.
- ^ "Dr. Soo-Kyung Lee Named FOXG1 Research Foundation Chief Scientific Officer". FOXG1 Research Foundation. Retrieved 2026-09-28.
- ^ Belluck, Pam (2018-04-23). "Infinitesimal Odds: A Scientist Finds Her Child's Rare Illness Stems From the Gene She Studies". The New York Times. ISSN 0362-4331. Retrieved 2026-09-28.