EIF3I

EIF3I
Mã định danh
Danh pháp	EIF3I, EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36, eukaryotic translation initiation factor 3 subunit I
ID ngoài	OMIM: 603911 HomoloGene: 2786 GeneCards: EIF3I
Mẫu hình biểu hiện RNA
	Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen
Chức năng phân tử	• GO:0001948, GO:0016582 protein binding; • translation initiation factor activity;
Thành phần tế bào	• extracellular exosome; • cytosol; • tế bào chất; • eukaryotic translation initiation factor 3 complex; • eukaryotic translation initiation factor 3 complex, eIF3m; • eukaryotic 43S preinitiation complex; • eukaryotic 48S preinitiation complex;
Quá trình sinh học	• translational initiation; • sinh tổng hợp protein; • formation of cytoplasmic translation initiation complex; • cytoplasmic translational initiation;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	8668
	n/a
	ENSG00000084623
	n/a
	Q13347
	n/a
	NM_003757; NM_001394168
	n/a
	NP_003748
	n/a
	Wikidata
Xem/Sửa Người

Tiểu đơn vị I của yếu tố khởi đầu dịch mã sinh vật nhân thực 3 (tiếng Anh: Eukaryotic translation initiation factor 3 subunit I) là protein ở người được mã hóa bởi gen EIF3I.^[2]^[3]^[4]

Tương tác

EIF3I có khả năng tương tác với TGF beta 1^[5] và EIF3A.^[3]^[6]^[7]

Xem thêm

Yếu tố khởi đầu sinh vật nhân thực 3 (eIF3)

Tham khảo

^ “Human PubMed Reference:”.
^ Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R (tháng 11 năm 1995). “A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor”. Nature. 377 (6549): 548–52. doi:10.1038/377548a0. PMID 7566156.
^ ^a ^b Asano K, Kinzy TG, Merrick WC, Hershey JW (tháng 2 năm 1997). “Conservation and diversity of eukaryotic translation initiation factor eIF3”. J. Biol. Chem. 272 (2): 1101–9. doi:10.1074/jbc.272.2.1101. PMID 8995409.
^ “Entrez Gene: EIF3S2 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa”.
^ Choy L, Derynck R (tháng 11 năm 1998). “The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response”. J. Biol. Chem. 273 (47): 31455–62. doi:10.1074/jbc.273.47.31455. PMID 9813058.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (tháng 10 năm 2003). “Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3”. Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.

Đọc thêm

Akoulitchev S, Mäkelä TP, Weinberg RA, Reinberg D (1995). “Requirement for TFIIH kinase activity in transcription by RNA polymerase II”. Nature. 377 (6549): 557–60. doi:10.1038/377557a0. PMID 7566158.
Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Méthot N, Rom E, Olsen H, Sonenberg N (1997). “The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170”. J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). “Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Galli-Stauber C, Raho G, Rossi D, Corona DF, Pirola B, Bonaglia MC, Zuffardi O, Sorrentino V (1998). “Genomic structure and chromosomal location of the human TGFbeta-receptor interacting protein-1 (TRIP-1) gene to 1p34.1”. FEBS Lett. 426 (2): 279–82. doi:10.1016/S0014-5793(98)00361-5. PMID 9599024.
Choy L, Derynck R (1998). “The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response”. J. Biol. Chem. 273 (47): 31455–62. doi:10.1074/jbc.273.47.31455. PMID 9813058.
Block KL, Vornlocher HP, Hershey JW (1998). “Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3”. J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.
Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME (2000). “Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2”. Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2836–9. doi:10.1073/pnas.050580997. PMC 16016. PMID 10706629.
McGonigle S, Beall MJ, Pearce EJ (2002). “Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response”. Biochemistry. 41 (2): 579–87. doi:10.1021/bi011407z. PMID 11781097.
Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). “Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3”. Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW (2004). “The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro”. J. Biol. Chem. 279 (10): 8946–56. doi:10.1074/jbc.M312745200. PMID 14688252.
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