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James Keeffe was an Irish Roman Catholic cleric who was the founder of St. Patrick's, Carlow College. He was Bishop of Kildare and Leighlin for over 35 years (1752–1787).^[1] He lived most of his time at Tullow, County Carlow.

He was preceded by Bishop James Gallagher in 1737 and succeeded by Bishop Daniel Delany in 1787, who was his co-adjutor Bishop and also helped in the foundation of Carlow College.