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Miriam Merad
Born
Paris, France
Education
Title
  • Dean for Translational Research and Therapeutic Innovation
  • Robin Chemers Neustein Professor of Immunology
  • Director, Marc and Jennifer Lipschultz Precision Immunology Institute (PrIISM)
Scientific career
Fields
InstitutionsIcahn School of Medicine at Mount Sinai

Miriam Merad (born 1969)[1] is an Algerian professor of cancer immunology. She serves as Dean for Translational Research and Therapeutic Innovation, the Robin Chemers Neustein Professor of Immunology, and Director of the Marc and Jennifer Lipschultz Precision Immunology Institute (PrIISM) at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York, NY. She co-received the 2018 William B. Coley Award for Distinguished Research in Basic Immunology.[2] She belongs to the United States National Academy of Sciences.[3] and the National Academy of Medicine.[4]

Early life

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Miriam Merad earned her M.D. from the medical school at the University of Algiers in 1985. She completed residency in hematology and oncology at Paris Diderot University.[5] She obtained a Master's degree in Biotechnology from Paris Diderot. She then moved to Stanford University and earned a PhD in the laboratory of Edgar Engleman.[6] Her clinical training in hematology/oncology and bone marrow transplantation at Hôpital Saint-Louis and Institut Gustave Roussy in Paris sparked her interest in immunotherapy.

Career

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Merad collaborated with Irving Weissman at Stanford. They revised understanding of macrophage and dendritic cell ontogeny.[7] ISMMS recruited her in 2004. She received an Endowed Chair in Cancer Immunology in 2014.[8] In 2016, ISMMS appointed her Director of the Immunology Institute.[9] In August 2023, she became founding Chair of the Department of Immunology and Immunotherapy (DII) at ISMMS. The department focuses on immune system biology and its effects on health and disease. In April 2024, ISMMS named her Dean for Translational Research and Therapeutic Innovation.[10]

Research

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Merad's early work identified mechanisms controlling development and identity of tissue-resident dendritic cells and macrophages. Her laboratory established the embryonic origin of tissue-resident macrophages,[11] microglia,[12] and Langerhans cells.[13] These cells contribute to synaptic pruning, gut peristalsis, fat metabolism, and vascular integrity. Her team identified tissue-resident CD103+ dendritic cells, which specialize in anti-viral and anti-tumor immunity.

Merad's group examines how myeloid cell subsets drive inflammatory diseases. In 2021, Bigenwald, et al., reported that mitogen-activated protein kinase pathway mutations trigger senescence in hematopoietic progenitors. This skews differentiation toward mononuclear phagocytes and causes multisystem Langerhans Cell Histiocytosis.[14] In 2022, Chen, et al., and others reported that severe COVID-19 reduces tissue-resident lung alveolar macrophages, which aid repair, while increasing inflammatory monocytes and monocyte-derived macrophages.[15]

Merad's laboratory explores dendritic cells and macrophages in the tumor microenvironment.[1] Two macrophage lineages she defined appear in tumors. Their origins dictate roles in shaping the microenvironment. In human lung tumors, Casanova-Acebes, et al., reported in 2021 that tissue-resident macrophages cluster near early tumor cells. They increase invasiveness and activate regulatory T cells that shield tumors from immunity.[16] As tumors grow, tissue-resident macrophages shift to the periphery. Monocyte-derived macrophages then dominate.

In 2023, Park, et al., and others reported that TREM2 tumor macrophages suppress immunity. They limit natural killer cell recruitment and activity in lung adenocarcinoma models.[17] In 2020, Maier, et al., reported mature dendritic cells enriched in immunoregulatory molecules (mregDCs). These limit responses to immune checkpoint blockade.[18] In 2023, Magen, et al., and others reported niches where mregDCs operate in tumors.[19] In 2024, Park, et al., and others reported that aging shifts macrophages from protectors to disease drivers. They fuel cancer via immunosuppressive programs[20] and promote neurodegeneration via senescent monocytes. In 2025, Park, et al., reported strategies to reprogram aging-linked immune cells for healthier longevity.[21] Merad led a semi-finalist team in the XPRIZE Healthspan competition.[22] Merad co-founded the International Immunoschool in 2015 with researchers from Sorbonne University in Paris, France, and University of São Paulo in Brazil.[23] She published on cancer immunotherapy trials,[24] Long COVID classification,[25] immigrants' role in U.S. science,[26] and experiences as a mother scientist.[27]

Recognition

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Notable publications

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References

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  1. ^ a b Azvolinsky, Anna (April 1, 2019). "Cancer Vaxxer: A Profile of Miriam Merad". the-scientist.com. Retrieved June 15, 2025.
  2. ^ a b "Three Scientists to Receive Top Honors from the Cancer Research Institute for Outstanding Contributions to Cancer Immunology and Immunotherapy". cancerresearch.org. Cancer Research Institute. Retrieved 31 May 2019.
  3. ^ "2020 NAS Election". www.nasonline.org. Retrieved 28 April 2020.
  4. ^ "National Academy of Medicine Elects 100 New Members". www.nam.edu/. 9 October 2023. Retrieved 11 October 2023.
  5. ^ "miriam-merad, MD, PhD". icahn.mssm.edu. Retrieved 3 June 2019.
  6. ^ "Engleman Trainees 1983-present" (PDF). Retrieved 3 June 2019.
  7. ^ "Irving L. Weissman, MD". Retrieved 6 Dec 2022.
  8. ^ "miriam-merad, MD/PhD". icahn.mssm.edu. Retrieved 3 June 2019.
  9. ^ "The Tisch Cancer Institute and Precision Immunology Institute at Mount Sinai Launch Center for Computational Immunology". www.mountsinai.org/. Retrieved 15 Dec 2022.
  10. ^ "Icahn School of Medicine at Mount Sinai Names Miriam Merad, MD, PhD, as Dean for Translational Research and Therapeutic Innovation". www.newswise.com. Retrieved 2024-04-30.
  11. ^ Hashimoto, Daigo; Chow, Andrew; Noizat, Clara; Teo, Pearline; Beasley, Mary Beth; Leboeuf, Marylene; Becker, Christian D.; See, Peter; Price, Jeremy; Lucas, Daniel; Greter, Melanie; Mortha, Arthur; Boyer, Scott W.; Forsberg, E. Camilla; Tanaka, Masato; Van Rooijen, Nico; García-Sastre, Adolfo; Stanley, E. Richard; Ginhoux, Florent; Frenette, Paul S.; Merad, Miriam (2013). "Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes". Immunity. 38 (4): 792–804. doi:10.1016/j.immuni.2013.04.004. PMC 3853406. PMID 23601688.
  12. ^ Ginhoux, Florent; Greter, Melanie; Leboeuf, Marylene; Nandi, Sayan; See, Peter; Gokhan, Solen; Mehler, Mark F.; Conway, Simon J.; Ng, Lai Guan; Stanley, E. Richard; Samokhvalov, Igor M.; Merad, Miriam (2010). "Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages". Science. 330 (6005): 841–845. Bibcode:2010Sci...330..841G. doi:10.1126/science.1194637. PMC 3719181. PMID 20966214.
  13. ^ Ginhoux, Florent; Collin, Matthew P.; Bogunovic, Milena; Abel, Michal; Leboeuf, Marylene; Helft, Julie; Ochando, Jordi; Kissenpfennig, Adrien; Malissen, Bernard; Grisotto, Marcos; Snoeck, Hans; Randolph, Gwendalyn; Merad, Miriam (2007). "Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state". The Journal of Experimental Medicine. 204 (13): 3133–3146. doi:10.1084/jem.20071733. PMC 2150983. PMID 18086862. Retrieved 11 May 2022.
  14. ^ Bigenwald, Camille; Le Berichel, Jessica; Wilk, C. Matthias; Chakraborty, Rikhia; Chen, Steven T.; Tabachnikova, Alexandra; Mancusi, Rebecca; Abhyankar, Harshal; Casanova-Acebes, Maria; Laface, Ilaria; Akturk, Guray; Jobson, Jenielle; Karoulia, Zoi; Martin, Jerome C.; Grout, John; Rafiei, Anahita; Lin, Howard; Manz, Markus G.; Baccarini, Alessia; Poulikakos, Poulikos I.; Brown, Brian D.; Gnjatic, Sacha; Lujambio, Amaia; McClain, Kenneth L.; Picarsic, Jennifer; Allen, Carl E.; Merad, Miriam (2021). "BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology". Nature Medicine. 27 (5): 851–861. doi:10.1038/s41591-021-01304-x. PMC 9295868. PMID 33958797.
  15. ^ Chen, Steven T.; et al. (2022). "A shift in lung macrophage composition is associated with COVID-19 severity and recovery". Science Translational Medicine. 14 (662) eabn5168. doi:10.1126/scitranslmed.abn5168. PMC 10117220. PMID 36103512.
  16. ^ Casanova-Acebes, María; Dalla, Erica; Leader, Andrew M.; Leberichel, Jessica; Nikolic, Jovan; Morales, Blanca M.; Brown, Markus; Chang, Christie; Troncoso, Leanna; Chen, Steven T.; Sastre-Perona, Ana; Park, Matthew D.; Tabachnikova, Alexandra; Dhainaut, Maxime; Hamon, Pauline; Maier, Barbara; Sawai, Catherine M.; Agulló-Pascual, Esperanza; Schober, Markus; Brown, Brian D.; Reizis, Boris; Marron, Thomas; Kenigsberg, Ephraim; Moussion, Christine; Benaroch, Philippe; Aguirre-Ghiso, Julio A.; Merad, Miriam (2021). "Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells". Nature. 595 (7868): 578–584. Bibcode:2021Natur.595..578C. doi:10.1038/s41586-021-03651-8. PMC 8923521. PMID 34135508.
  17. ^ Park, Matthew D.; et al. (2023). "TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer". Nature Immunology. 24 (5): 792–801. doi:10.1038/s41590-023-01475-4. PMC 11088947. PMID 37081148.
  18. ^ Maier, Barbara; Leader, Andrew M.; Chen, Steven T.; Tung, Navpreet; Chang, Christie; Leberichel, Jessica; Chudnovskiy, Aleksey; Maskey, Shrisha; Walker, Laura; Finnigan, John P.; Kirkling, Margaret E.; Reizis, Boris; Ghosh, Sourav; d'Amore, Natalie Roy; Bhardwaj, Nina; Rothlin, Carla V.; Wolf, Andrea; Flores, Raja; Marron, Thomas; Rahman, Adeeb H.; Kenigsberg, Ephraim; Brown, Brian D.; Merad, Miriam (2020). "A conserved dendritic-cell regulatory program limits antitumour immunity". Nature. 580 (7802): 257–262. Bibcode:2020Natur.580..257M. doi:10.1038/s41586-020-2134-y. PMC 7787191. PMID 32269339.
  19. ^ Magen, Assaf; et al. (2023). "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma". Nature Medicine. 29 (6): 1389–1399. doi:10.1038/s41591-023-02345-0. PMC 11027932. PMID 37322116.
  20. ^ Park, Matthew D.; et al. (2024). "Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis". Science. 386 (6720) eadn0327. Bibcode:2024Sci...386n0327P. doi:10.1126/science.adn0327. PMC 7616710. PMID 39236155.
  21. ^ Park, Matthew D.; Yatim, Nader; Zhang, Jing; Cho, Byuri Angela; Yoo, Seong-Keun; Schaefer, Maximilian M.; Chowell, Diego; Puleston, Daniel J.; Merad, Miriam (2025). "Restoring resident tissue macrophages to combat aging and cancer". Nature Aging. 5 (8): 1383–1392. doi:10.1038/s43587-025-00898-y. PMID 40813807. Retrieved 4 September 2025.
  22. ^ "Mount Sinai Researchers in Semifinals of $101 Million XPRIZE Healthspan, a Competition Seeking Innovative Approaches to Aging Well". www.globenewswire.com/ (Press release). 12 May 2025. Retrieved 2025-09-04.
  23. ^ Vabret, Nicolas; Mateus-Tique, Jaime; Salmon, Hélène; Martin, Jérôme C.; Mateo, Véronique; Serrano, Sandra; Lemoine, François; Chammas, Roger; Merad, Miriam (2024). "Online immunology education for a global world". Nature Reviews Immunology. 24 (9): 615–616. doi:10.1038/s41577-024-01066-w. PMID 38997523. Retrieved 4 September 2025.
  24. ^ Marron, Thomas U.; Galsky, Matthew D.; Taouli, Bachir; Fiel, Maria Isabel; Ward, Stephen; Kim, Edward; Yankelevitz, David; Doroshow, Deborah; Guttman-Yassky, Emma; Ungar, Benjamin; Mehandru, Saurabh; Golas, Benjamin J.; Labow, Daniel; Sfakianos, John; Nair, Sujit S.; Chakravarty, Dimple; Buckstein, Michael; Song, Xiaoyu; Kenigsberg, Effi; Gnjatic, Sacha; Brown, Brian D.; Sparano, Joseph; Tewari, Ashutosh; Schwartz, Myron; Bhardwaj, Nina; Merad, Miriam (2022). "Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery". Nature Medicine. 28 (4): 626–629. doi:10.1038/s41591-022-01681-x. PMC 9901535. PMID 35347282.
  25. ^ Mehandru, Saurabh; Merad, Miriam (2022). "Pathological sequelae of long-haul COVID". Nature Immunology. 23 (2): 194–202. doi:10.1038/s41590-021-01104-y. PMC 9127978. PMID 35105985.
  26. ^ Brown, Brian D.; Leader, Andrew M.; Vilcek, Jan; Merad, Miriam (2020). ""America First" Will Destroy U.S. Science". Cell. 183 (4): 841–844. doi:10.1016/j.cell.2020.09.025. PMC 7500439. PMID 32949492.
  27. ^ Merad, Miriam (2020). "Reflections from a mother scientist". Nature Medicine. 26 (9): 1316. doi:10.1038/s41591-020-1052-8. PMID 32839622. Retrieved 12 May 2022.
  28. ^ "Miriam Merad, MD, PhD, Awarded French Knighthood for Pioneering Contributions to Science and Medicine". Retrieved 4 September 2025.
  29. ^ "Sjöberg Laureate discovered new targets for cancer therapies in the immune system". YouTube. 12 February 2025. Retrieved 13 February 2025.
  30. ^ "CLASS OF 2025". Retrieved 10 February 2025.
  31. ^ "Class of 2024". Retrieved 10 February 2025.
  32. ^ "Global Reach: Inserm Celebrates in Washington, DC, 60 Years of Research and Innovation". 25 October 2024. Retrieved 10 February 2025.
  33. ^ "Les lauréats des Prix Fondation ARC Léopold Griffuel". Retrieved 10 February 2025.
  34. ^ "About the Academy of Immuno-Oncology". Retrieved 15 September 2023.
  35. ^ "International Union of Immunological Societies". Retrieved 20 February 2020.
  36. ^ "The American Society for Clinical Investigation". Retrieved 3 June 2019.
  37. ^ "Miriam Merad". www.nasonline.org/. Retrieved 12 May 2022.
  38. ^ "Highly Cited Researchers". www.clarivate.com/. Retrieved 6 May 2022.
  39. ^ "Miriam Merad". Carnegie Corporation of New York. Retrieved June 25, 2024.
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