A nuclear protein is a protein found in the cell nucleus.[1] Proteins are transported inside the nucleus with they help of the nuclear pore complex, which acts a barrier between cytoplasm and nuclear membrane. Many nuclear proteins contain positively charged amino acids such as Lysine and Arginine which acts as a signal to allow the protein to get transported into the nucleus while maintaining their fold.[citation needed] The import and export of proteins through the nuclear pore complex plays a fundamental role in gene regulation and other biological functions.[2][3]
The Nuclear Protein Database (NPD) is a database of around 1,000 proteins localized to the vertebrate cell nucleus. Proteins are searchable by name, motif, nuclear compartment or a keyword term.[4][5]
References
[edit]- ^ "MeSH Browser". meshb.nlm.nih.gov. Retrieved 2019-05-12.
- ^ Freitas N, Cunha C (December 2009). "Mechanisms and signals for the nuclear import of proteins". Current Genomics. 10 (8): 550–7. doi:10.2174/138920209789503941. PMC 2817886. PMID 20514217.
- ^ Jühlen R, Fahrenkrog B (December 2018). "Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease". Histochemistry and Cell Biology. 150 (6): 593–605. doi:10.1007/s00418-018-1748-8. PMID 30361777. S2CID 53030528.
- ^ Dellaire, G.; Farrall, R.; Bickmore, W. A. (2003-01-01). "The Nuclear Protein Database (NPD): sub-nuclear localisation and functional annotation of the nuclear proteome". Nucleic Acids Research. 31 (1): 328–330. doi:10.1093/nar/gkg018. ISSN 1362-4962. PMC 165465. PMID 12520015.
- ^ "Nuclear Protein Database (NPD)". webapps.igc.ed.ac.uk. Retrieved 12 October 2025.
External links
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