+ reduced
ferredoxin
Wiki Article
Pentalenic acid synthase
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| Pentalenic acid synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.15.11 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pentalenic acid synthase (EC 1.14.15.11, CYP105D7, sav7469 (gene)) is an enzyme with systematic name 1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase.[1] This enzyme catalyses the following chemical reaction
Pentalenic acid synthase from Streptomyces avermitilis is an oxidoreductase which uses molecular oxygen to insert a hydroxy group into 1-deoxypentalenic acid. It requires ferredoxin to transfer electrons to the cytochrome P450 active site.[2]
References
[edit]- ^ Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H (January 2011). "Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis". The Journal of Antibiotics. 64 (1): 65–71. doi:10.1038/ja.2010.135. PMC 3030646. PMID 21081950.
- ^ Enzyme 1.14.15.11 at KEGG Pathway Database.
External links
[edit]- Pentalenic+acid+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
