| Identifiers | |||||||
|---|---|---|---|---|---|---|---|
| Organism | |||||||
| Symbol | PB2 | ||||||
| Entrez | 956536 | ||||||
| PDB | 2VQZ | ||||||
| RefSeq (Prot) | NP_040987.1 | ||||||
| UniProt | P21428 | ||||||
| Other data | |||||||
| Chromosome | Genome: 0 - 0 Mb | ||||||
| |||||||
Influenza virus polymerase basic protein 2 (PB2) is a core subunit of the viral RNA-dependent RNA polymerase complex that is essential for both transcription and replication of the negative-strand RNA genome.[1] PB2 binds capped host pre-mRNAs and participates in the “cap snatching” process that generates primers for viral mRNA synthesis.[2] PB2 also acts as a key determinant of host range and pathogenicity in different influenza A strains, including through amino-acid substitutions such as the lysine at position 627.[3] In addition, PB2 is imported into the mitochondrial matrix, where it may influence viral replication and host–virus interactions.[4]
References
[edit]- ^ "Polymerase basic protein 2". UniProt. P21428.
- ^ Bouvier NM, Palese P (September 2008). "The biology of influenza viruses". Vaccine. 26 (Suppl 4): D49 – D53. doi:10.1016/j.vaccine.2008.07.039. PMC 3074182. PMID 19230160.
- ^ Kuzuhara T, Kise D, Yoshida H, Horita T, Murazaki Y, Nishimura A, et al. (March 2009). "Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue". The Journal of Biological Chemistry. 284 (11): 6855–6860. doi:10.1074/jbc.C800224200. PMC 2652293. PMID 19144639.
- ^ Long JC, Fodor E (October 2016). "The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix". Journal of Virology. 90 (19): 8729–8738. doi:10.1128/JVI.01384-16. PMC 5021425. PMID 27440905.