TSEN15

Tsen15
Identifiers
Aliases	5730449L18RikAL023077Sen15tRNA splicing endonuclease subunit 15
External IDs	HomoloGene: 12002; GeneCards: [1]; OMA:- orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1|1 G2 Start 152,246,486 bp End 152,262,439 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in yolk sac epiblast embryo ventricular zone embryo quadriceps femoris muscle olfactory bulb placenta heart skeletal muscle tissue n/a More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA-intron endonuclease activity molecular function nucleic acid binding nuclease activity Cellular component nucleolus nucleus cellular component Biological process mRNA processing tRNA splicing, via endonucleolytic cleavage and ligation RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing biological process nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 66637 n/a Ensembl ENSMUSG00000014980 n/a UniProt Q8R3W5 Q8R3W5 RefSeq (mRNA) NM_025677 n/a RefSeq (protein) NP_079953 NP_079953 Location (UCSC) Chr 1: 152.25 – 152.26 Mb n/a PubMed search [1] n/a
Wikidata
View/Edit Human

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.^[2][3][4]

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[4]

Interactions

C1orf19 has been shown to interact with TSEN2.^[5]

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
3. Song J, Markley JL (February 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". Journal of Molecular Biology. 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.
4. "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".
5. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.

Further reading

• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.