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Tabernamine

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Tabernamine
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C40H48N4O2/c1-5-23-15-22-16-32-37-28(13-14-44(20-22)39(23)32)27-12-11-25(17-34(27)42-37)30-18-29-24(6-2)21-43(3)35(36(29)40(45)46-4)19-31-26-9-7-8-10-33(26)41-38(30)31/h6-12,17,22-23,29-30,32,35-36,39,41-42H,5,13-16,18-21H2,1-4H3/b24-6-
    Key: MTARGWPMLJBYNG-UMDHDWCXSA-N
  • CCC1CC2CC3C1N(C2)CCC4=C3NC5=C4C=CC(=C5)C6CC\7C(C(CC8=C6NC9=CC=CC=C89)N(C/C7=C/C)C)C(=O)OC
Properties
C40H48N4O2
Molar mass 616.850 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Tabernamine is a bisindole isolate of Tabernaemontana with anticancer activity.[1]

Derivatives

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19,20-dihydrotabernamine is said to have potent acetylcholinesterase inhibitor activity greater than galantamine.

Notes

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  1. ^ Nge, Choy-Eng; Chong, Kam-Weng; Thomas, Noel F.; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok (2016). "Ibogan, aspidosperman, vincamine, and bisindole alkaloids from a Malayan Tabernaemontana corymbosa: Iboga alkaloids with C-20α substitution". Journal of Natural Products. 79 (5): 1388–1399. Bibcode:2016JNAtP..79.1388N. doi:10.1021/acs.jnatprod.6b00129. PMID 27077800.{{cite journal}}: CS1 maint: multiple names: authors list (link)