Transdermal spray

A metered-dose transdermal spray delivers a drug to the skin surface for subsequent transdermal absorption. It functions similarly to other transdermal dosage forms such as patches and gels.^[1]

In metered-dose transdermal sprays, a volatile solvent system rapidly dries after application, leaving the drug concentrated in or on the stratum corneum as a reservoir or depot from which it is released over time.^[2]

An example of an approved transdermal spray is Evamist (estradiol transdermal spray), indicated for the treatment of moderate to severe vasomotor symptoms due to menopause.^[3]

References

^ Algın-Yapar, Esra; İnal, Özlem (2014). "Transdermal Spray in Hormone Delivery". Tropical Journal of Pharmaceutical Research. 13 (3). doi:10.4314/tjpr.v13i3.23.
^ Mandal, U. K.; Jalalpure, S.; Gadade, D. (2016). "A Review on Transdermal Spray: Formulation Aspect" (PDF). Mathews Journal of Pharmaceutical Science. 1 (1). Retrieved 2026-04-17.
^ "EVAMIST (estradiol transdermal spray) prescribing information" (PDF). U.S. Food and Drug Administration. Retrieved 2026-04-17.

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[Algin2014-1] Algın-Yapar, Esra; İnal, Özlem (2014). "Transdermal Spray in Hormone Delivery". Tropical Journal of Pharmaceutical Research. 13 (3). doi:10.4314/tjpr.v13i3.23.

[Mandal2016-2] Mandal, U. K.; Jalalpure, S.; Gadade, D. (2016). "A Review on Transdermal Spray: Formulation Aspect" (PDF). Mathews Journal of Pharmaceutical Science. 1 (1). Retrieved 2026-04-17.

[EvamistLabel-3] "EVAMIST (estradiol transdermal spray) prescribing information" (PDF). U.S. Food and Drug Administration. Retrieved 2026-04-17.

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