Mo Gaffney (gebore 5 November 1958) is 'n Amerikaanse aktrise en skryfster. Sy is bekend vir haar rolle in die rolprente Happy, Texas (1999) en Absolutely Fabulous: The Movie (2016).
- 1998: Inconceivable
- 1999: Happy, Texas
- 1999: My X-Girlfriend's Wedding Reception
- 1999: The Basement and the Kitchen
- 2016: Absolutely Fabulous: The Movie
- 1992: Absolutely Fabulous
- 1992: Women Aloud
- 1993: The Mo Show
- 1996: Tracey Takes On...
- 2000: Normal, Ohio
- 2003: Run of the House
- 2013: In Reality
- 2016: The Truth of Tears
- Do the Voice
- 1994: Days Like This
- 1995: The Kathy & Mo Show: The Dark Side
- 2011: My Freakin' Family
- 2012: The Unprofessional
- 2013: Continuing Fred