سوف يشهد الدور الثاني مشاركة أعلى 28 فريق بالتصنيف ينضم اليهم 12 فائز من الدور الأول. جرى تقسيم هذه الفرق إلى عشر مجموعات من أربعة فرق، في مارينا دا غلوريا بريو دي جانيرو، البرازيل يوم 30 يوليو 2011.[1]
من المقرر أن تلعب المباريات من 1 يونيو 2012 إلى 6 سبتمبر 2013. الفائزون من كل مجموعة يتقدمون إلى الدور الثالث.
^FIFA awarded Zambia a 3–0 win as a result of Sudan fielding the ineligible player سيف الدين علي مساوي. The match originally ended 2–0 to Sudan.[2][3]
^FIFA awarded Congo a 3–0 win as a result of Burkina Faso fielding the ineligible player Herve Zengue. The match originally ended 0–0.[4]
^FIFA awarded Niger a 3–0 win as a result of Gabon fielding the ineligible player تشارلي موسونو. The match originally ended 0–0.[5][6]
^The fixtures Kenya v Nigeria on 7 يونيو 2013 and Namibia v Nigeria on 14 يونيو 2013 were moved to 5 يونيو and 12 يونيو respectively to allow Nigeria to participate in the كأس القارات 2013.[7]
^Mali's opening home match in the World Cup qualifiers against Algeria was played at a neutral venue due to انقلاب مالي 2012.[8]
^Libya's opening home match in the World Cup qualifiers against Cameroon was played at a neutral venue. The match was ordered to be played behind closed doors due to security concerns, but the official match report indicates a small crowd was present.[9]
^Senegal must play their last two home matches in the World Cup qualifiers against Angola and Uganda at a neutral venue, due to a one-year ban from playing at their home stadium imposed by the CAF following riots in their تصفيات كأس الأمم الأفريقية لكرة القدم 2013 match against Côte d'Ivoire.[10]