CCL15

CCL15
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 2HCC
Identifikatori
Aliasi	CCL15
Vanjski ID-jevi	OMIM: 601393 HomoloGene: 130802 GeneCards: CCL15
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q12 Početak 35,996,440 bp[1] Kraj 36,001,553 bp[1]
Ontologija gena Molekularna funkcija • cytokine activity • heparin binding • CCR chemokine receptor binding • chemoattractant activity • signaling receptor binding • chemokine activity Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • G protein-coupled receptor signaling pathway • monocyte chemotaxis • chemokine-mediated signaling pathway • cell-cell signaling • cellular response to tumor necrosis factor • cellular calcium ion homeostasis • neutrophil chemotaxis • Hemotaksija • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cellular response to interleukin-1 • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cell chemotaxis • lymphocyte chemotaxis • inflammatory response • GO:0072468 Transdukcija signala • positive chemotaxis • regulation of signaling receptor activity • eosinophil chemotaxis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6359	n/a
Ensembl	ENSG00000275718 ENSG00000275528	n/a
UniProt	Q16663	n/a
RefSeq (mRNK)	NM_032965 NM_004167 NM_032964	n/a
RefSeq (bjelančevina)	NP_116741	n/a
Lokacija (UCSC)	Chr 17: 36 – 36 Mb	n/a
PubMed pretraga	[2]	n/a
Wikipodaci
Pogledaj/uredi – čovjek

Hemokinski (C-C motivni) ligand 15
Identifikatori
Simbol	CCL15
Alt. simboli	SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B
NCBI gen	6359
HGNC	10613
OMIM	601393
PDB	2HCC
RefSeq	NM_032965
UniProt	Q16663
Ostali podaci
Lokus	Hrom. 17 q11.2
Pretraga za Strukture Swiss-model Domene InterPro

Hemokinski (C-C motivni) ligand 15 (CCL15) jest mali citokin koji pripada porodici CC hemokina, koji je poznat i kao leukotaktin-1, MIP5 i HCC-2. CCL15 se eksprimira u jetri, tankom i debelom crijevu, te u određenim leukocitima i makrofagima pluća.^[3] Hemotaksijski
je za neutrofile, monocite i limfocite i izaziva učinke vezanjem na površinu ćelija hemokinskih receptora poput CCR1 i CCR3.^[4][5] Ljudski CCL15 gen obuhvata četiri egzona i nalazi se u orijentaciji od glave do repa na hromosomu 17 sa genom drugog CC hemokina poznatog kao CCL14.^[6]

Reference

1. ENSG00000275528 GRCh38: Ensembl release 89: ENSG00000275718, ENSG00000275528 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998.
   
4. Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
5. Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.
6. Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.

Vanjski linkovi

• CCL15 GeneCard