U biohemiji , dvospecifična kinaza (EC 2.7.12.1 ) je kinaza koja može djelovati i kao tirozin-kinaza i serin/treonin kinaza .
MEK , uključena u MAP puteve , glavni su primjeri kinaza dvostruke specifičnosti. Drugi uobičajeni primjeri uključuju:
Sistematski naziv ove klase enzima je ATP:protein-fosfotransferaza (Ser/Thr- i Tyr-fosforilirajuća fosfotransferaza) .
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Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase" . EMBO J . 14 (8): 1655–63. PMC 398258 . PMID 7737118 .
Menegay HJ, Myers MP, Moeslein FM, Landreth GE. "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell Sci . 113 : 3241–53. PMID 10954422 .
Cleghon V; Sibbet, G; Kinstrie, R; Cleghon, T; Rylatt, M; Morrison, DK; Cleghon, V (2003). "dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila" . Biochem. J . 374 (Pt 2): 381–91. doi :10.1042/BJ20030500 . PMC 1223608 . PMID 12786602 .
Šablon:Unuarćelisjki signalni peptidi i proteini
Šablon:Serin/treonine-specifične protein-kinaze