ETS2

ETS2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4BQA, 4MHV
Identifikatori
Aliasi	ETS2
Vanjski ID-jevi	OMIM: 164740 MGI: 95456 HomoloGene: 3838 GeneCards: ETS2
Lokacija gena (čovjek) Hrom. Hromosom 21 (čovjek)[1] Bend 21q22.2 Početak 38,805,183 bp[1] Kraj 38,824,955 bp[1]
Lokacija gena (miš) Hrom. Hromosom 16 (miš)[2] Bend 16 C4|16 56.64 cM Početak 95,502,942 bp[2] Kraj 95,522,095 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 vezivanje za proteine • glucocorticoid receptor binding • protein domain specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • ćelijska membrana • nukleoplazma • jedro • citosol Biološki proces • skeletal system development • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • ectodermal cell fate commitment • mesoderm development • primitive streak formation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2114	23872
Ensembl	ENSG00000157557	ENSMUSG00000022895
UniProt	P15036	P15037
RefSeq (mRNK)	NM_001256295 NM_005239	NM_011809
RefSeq (bjelančevina)	NP_001243224 NP_005230	NP_035939
Lokacija (UCSC)	Chr 21: 38.81 – 38.82 Mb	Chr 16: 95.5 – 95.52 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein C-ETS2 jest protein koji je kod ljudi kodiran genom ETS2 sa hromosoma 21.^[5][6] Protein kodiran ovim genom pripada ETS porodici transkripcijskih faktora.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 469 aminokiselina, a molekulska težina 53.001 Da.^[5]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MNDFGIKNMD		QVAPVANSYR		GTLKRQPAFD		TFDGSLFAVF		PSLNEEQTLQ
EVPTGLDSIS		HDSANCELPL		LTPCSKAVMS		QALKATFSGF		KKEQRRLGIP
KNPWLWSEQQ		VCQWLLWATN		EFSLVNVNLQ		RFGMNGQMLC		NLGKERFLEL
APDFVGDILW		EHLEQMIKEN		QEKTEDQYEE		NSHLTSVPHW		INSNTLGFGT
EQAPYGMQTQ		NYPKGGLLDS		MCPASTPSVL		SSEQEFQMFP		KSRLSSVSVT
YCSVSQDFPG		SNLNLLTNNS		GTPKDHDSPE		NGADSFESSD		SLLQSWNSQS
SLLDVQRVPS		FESFEDDCSQ		SLCLNKPTMS		FKDYIQERSD		PVEQGKPVIP
AAVLAGFTGS		GPIQLWQFLL		ELLSDKSCQS		FISWTGDGWE		FKLADPDEVA
RRWGKRKNKP		KMNYEKLSRG		LRYYYDKNII		HKTSGKRYVY		RFVCDLQNLL
GFTPEELHAI		LGVQPDTED

Interakcije

Pokazalo se da ETS2 ima interakcije sa:

• C-jun,^[7]
• Ciklin-ovisna kinaza 10,^[8]
• ERG,^[7]
• MYB,^[9] and
• ZMYND11.^[10]

Reference

1. GRCh38: Ensembl release 89: ENSG00000157557 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022895 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dwyer J, Li H, Xu D, Liu JP (Oct 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Annals of the New York Academy of Sciences. 1114 (1): 36–47. Bibcode:2007NYASA1114...36D. doi:10.1196/annals.1396.022. PMID 17986575. S2CID 44532648.
6. "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)".
7. Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". The Journal of Biological Chemistry. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186.
8. Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.
9. Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (Feb 1992). "Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1291–5. Bibcode:1992PNAS...89.1291D. doi:10.1073/pnas.89.4.1291. PMC 48435. PMID 1741383.
10. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.

Dopunska literatura

• Boulukos KE, Pognonec P, Sariban E, Bailly M, Lagrou C, Ghysdael J (Mar 1990). "Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators". Genes & Development. 4 (3): 401–9. doi:10.1101/gad.4.3.401. PMID 2186967.
• Watson DK, Mavrothalassitis GJ, Jorcyk CL, Smyth FE, Papas TS (Oct 1990). "Molecular organization and differential polyadenylation sites of the human ETS2 gene". Oncogene. 5 (10): 1521–7. PMID 2250910.
• Watson DK, McWilliams MJ, Lapis P, Lautenberger JA, Schweinfest CW, Papas TS (Nov 1988). "Mammalian ets-1 and ets-2 genes encode highly conserved proteins". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 7862–6. Bibcode:1988PNAS...85.7862W. doi:10.1073/pnas.85.21.7862. PMC 282297. PMID 2847145.
• Watson DK, McWilliams-Smith MJ, Nunn MF, Duesberg PH, O'Brien SJ, Papas TS (Nov 1985). "The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active". Proceedings of the National Academy of Sciences of the United States of America. 82 (21): 7294–8. Bibcode:1985PNAS...82.7294W. doi:10.1073/pnas.82.21.7294. PMC 391330. PMID 2997781.
• Le Beau MM, Rowley JD, Sacchi N, Watson DK, Papas TS, Diaz MO (Nov 1986). "Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia". Cancer Genetics and Cytogenetics. 23 (3): 269–74. doi:10.1016/0165-4608(86)90189-5. PMID 3021321.
• Fujiwara S, Fisher RJ, Seth A, Bhat NK, Showalter SD, Zweig M, Papas TS (Feb 1988). "Characterization and localization of the products of the human homologs of the v-ets oncogene". Oncogene. 2 (2): 99–103. PMID 3285299.
• Sumarsono SH, Wilson TJ, Tymms MJ, Venter DJ, Corrick CM, Kola R, Lahoud MH, Papas TS, Seth A, Kola I (Feb 1996). "Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice". Nature. 379 (6565): 534–7. Bibcode:1996Natur.379..534H. doi:10.1038/379534a0. PMID 8596630. S2CID 4365956.
• Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". The Journal of Biological Chemistry. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186.
• Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J (Apr 1999). "Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1". The Journal of Biological Chemistry. 274 (18): 12910–6. doi:10.1074/jbc.274.18.12910. PMID 10212281.
• Jayaraman G, Srinivas R, Duggan C, Ferreira E, Swaminathan S, Somasundaram K, Williams J, Hauser C, Kurkinen M, Dhar R, Weitzman S, Buttice G, Thimmapaya B (Jun 1999). "p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter". The Journal of Biological Chemistry. 274 (24): 17342–52. doi:10.1074/jbc.274.24.17342. PMID 10358095.
• Kilpatrick LM, Kola I, Salamonsen LA (Jul 1999). "Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells". Biology of Reproduction. 61 (1): 120–6. doi:10.1095/biolreprod61.1.120. PMID 10377039.
• Rameil P, Lécine P, Ghysdael J, Gouilleux F, Kahn-Perlès B, Imbert J (Apr 2000). "IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells". Oncogene. 19 (17): 2086–97. doi:10.1038/sj.onc.1203542. PMID 10815800.
• Park US, Park SK, Lee YI, Park JG, Lee YI (Jul 2000). "Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells". Oncogene. 19 (30): 3384–94. doi:10.1038/sj.onc.1203674. PMID 10918595.
• Pastorcic M, Das HK (Nov 2000). "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene". The Journal of Biological Chemistry. 275 (45): 34938–45. doi:10.1074/jbc.M005411200. PMID 10942770.
• Smith JL, Schaffner AE, Hofmeister JK, Hartman M, Wei G, Forsthoefel D, Hume DA, Ostrowski MC (Nov 2000). "ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice". Molecular and Cellular Biology. 20 (21): 8026–34. doi:10.1128/MCB.20.21.8026-8034.2000. PMC 86413. PMID 11027273.
• Mullick J, Anandatheerthavarada HK, Amuthan G, Bhagwat SV, Biswas G, Camasamudram V, Bhat NK, Reddy SE, Rao V, Avadhani NG (May 2001). "Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter". The Journal of Biological Chemistry. 276 (21): 18007–17. doi:10.1074/jbc.M100671200. PMID 11279115.
• Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.
• Ezashi T, Ghosh D, Roberts RM (Dec 2001). "Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4". Molecular and Cellular Biology. 21 (23): 7883–91. doi:10.1128/MCB.21.23.7883-7891.2001. PMC 99954. PMID 11689681.
• Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (Dec 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ (Aug 2012). "Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors". Proceedings of the National Academy of Sciences of the United States of America. 109 (32): 13016–21. Bibcode:2012PNAS..10913016I. doi:10.1073/pnas.1120299109. PMC 3420197. PMID 22826236.

Vanjski linkovi

• Drosophila pointed - The Interactive Fly