Katepsin K

Katepsin K
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1MEM, 3KWB, 3KX1, 4X6J, 1AYW, 3KW9, 1YT7, 1AU2, 4X6H, 1Q6K, 1YK7, 1ATK, 3C9E, 1AYV, 1BGO, 4N8W, 7PCK, 4DMX, 4X6I, 1NL6, 1TU6, 3O0U, 1AU4, 3OVZ, 3KWZ, 2ATO, 3O1G, 1AU0, 1BY8, 1SNK, 2AUZ, 4DMY, 4N79, 1AYU, 1U9X, 1YK8, 1AU3, 1U9V, 2BDL, 1VSN, 1U9W, 2AUX, 2R6N, 3H7D, 1NLJ, 5J94, 4YVA, 4YV8
Identifikatori
Aliasi	CTSK
Vanjski ID-jevi	OMIM: 601105 MGI: 107823 HomoloGene: 68053 GeneCards: CTSK
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q21.3 Početak 150,794,880 bp[1] Kraj 150,809,577 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3 F2.1|3 40.74 cM Početak 95,406,567 bp[2] Kraj 95,416,673 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • fibronectin binding • cysteine-type peptidase activity • collagen binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • cysteine-type endopeptidase activity • hydrolase activity • proteoglycan binding • serine-type endopeptidase activity Ćelijska komponenta • citoplazma • extracellular region • endolysosome lumen • Lizozom • Vanćelijsko • nukleoplazma • intracellular membrane-bounded organelle • lysosomal lumen Biološki proces • intramembranous ossification • positive regulation of protein targeting to mitochondrion • extracellular matrix disassembly • bone resorption • Proteoliza • toll-like receptor signaling pathway • regulation of autophagy of mitochondrion • collagen catabolic process • proteolysis involved in cellular protein catabolic process • regulation of keratinocyte differentiation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1513	13038
Ensembl	ENSG00000143387	ENSMUSG00000028111
UniProt	P43235	P55097
RefSeq (mRNK)	NM_000396	NM_007802
RefSeq (bjelančevina)	NP_000387	NP_031828
Lokacija (UCSC)	Chr 1: 150.79 – 150.81 Mb	Chr 3: 95.41 – 95.42 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Katepsin K (EC 3.4.22.38 ili katepsin O2 je katepsinski enzim iz porodice cistein peptidaza.^{[5][6][7][8][9][10][11][12]}

Katepsin K katalizira hemijsku reakciju u kojoj se odvija:

široka proteolitska aktivnost na malim molekulama supstrata. Glavna odrednica specifičnosti je P2, koja je prvenstveno na pozicijama leucina metionina > fenilalanina, uz odsustvo arginina

Ovaj oblik katepsina, kod sisara se prominentno ispoljava u osteoklastima.

Reference

1. GRCh38: Ensembl release 89: ENSG00000143387 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028111 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inaoka, T., Bilbe, G., Ishibashi, O., Tezuka, K., Kumegawa, M. and Kokubo, T. (1995). "Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206: 89–96. PMID 7818555.
6. Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.
7. Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
8. Nelson D. L., Cox M. M. (2013): Lehninger principles of biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.
9. Alberts B. (2002)ː Molecular biology of the cell. Garland Science, New York, ISBN 0-8153-3218-1.
10. Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
11. Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.
12. Bossard, M.J., Tomaszek, T.A., Thompson, S.K., Amegadzie, B.Y., Hanning, C.R., Jones, C., Kurdyla, J.T., McNulty, D.E., Drake, F.H., Gowen, M. and Levy, M.A. (1996). "Proteolytic activity of human osteoclast cathepsin K - Expression, purification, activation, and substrate identification". J. Biol. Chem. 271: 12517–12524. PMID 8647860.

Vanjski linkovi

• Cathepsin K na US National Library of Medicine Medical Subject Headings (MeSH)