RPL36A
Podjedinica 60S ribosomskog proteina L36a je protein koji je kod ljudi kodiran genom RPL36A.[3][4]
Citoplazmatski ribosomi , organele koje kataliziraju sintezu proteina, sastoje se od male 40S i velike 60S podjedinice. Ove podjedinice zajedno se sastoje od četiri tipa RNK i približno 80 strukturno različitih proteina. Ovaj gen kodira ribosomani protein koji je komponenta podjedinice 60S. Protein, koji ima sličnu sekvencu sa ribosomnim proteinom kvasca L44, pripada porodici ribosomnih proteina L44E (L36AE). Iako se ovaj gen naziva ribosomni protein L44 (RPL44), njegov službeni naziv je ribosomni protein L36a (RPL36A). Ovaj gen i ljudski gen zvanično zvani ribosomni protein sličan L36a (RPL36AL) kodiraju gotovo identične proteine; međutim, oni su različiti geni. Kao što je tipskoo za gene koji kodiraju ribosomske proteine, postoji više obrađenih pseudogena ovog gena raspršenih širom genoma.[4]
Aminokiaelinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 106 aminokiselina, а molekulska težina 12.441 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MVNVPKTRRT | FCKKCGKHQP | HKVTQYKKGK | DSLYAQGKRR | YDRKQSGYGG | ||||
| QTKPIFRKKA | KTTKKIVLRL | ECVEPNCRSK | RMLAIKRCKH | FELGGDKKRK | ||||
| GQVIQF |
- C: Cistein
- D: Asparaginska kiselina
- E: Glutaminska kiselina
- F: Fenilalanin
- G: Glicin
- H: Histidin
- I: Izoleucin
- K: Lizin
- L: Leucin
- M: Metionin
- N: Asparagin
- P: Prolin
- Q: Glutamin
- R: Arginin
- S: Serin
- T: Treonin
- V: Valin
- W: Triptofan
- Y: Tirozin
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000241343 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dixit VM, Hennessy SW, Grant GA, Rotwein P, Frazier WA (Sep 1986). "Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin". Proc Natl Acad Sci U S A. 83 (15): 5449–53. Bibcode:1986PNAS...83.5449D. doi:10.1073/pnas.83.15.5449. PMC 386304. PMID 3461443.
- ^ a b "Entrez Gene: RPL36A ribosomal protein L36a".
- ^ "UniProt, P83881". Pristupljeno 26. 8. 2021.
Dopunska literatura
[uredi | uredi izvor]- Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
- Davies MS, Henney A, Ward WH, Craig RK (1987). "Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein". Gene. 45 (2): 183–91. doi:10.1016/0378-1119(86)90253-2. PMID 3542712.
- Oeltjen JC, Liu X, Lu J, et al. (1995). "Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci". Mamm. Genome. 6 (5): 334–8. doi:10.1007/BF00364796. PMID 7626884. S2CID 22686077.
- Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
- Vorechovský I, Vetrie D, Holland J, et al. (1994). "Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22". Genomics. 21 (3): 517–24. doi:10.1006/geno.1994.1310. PMID 7959728.
- Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
- Oeltjen JC, Malley TM, Muzny DM, et al. (1997). "Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains". Genome Res. 7 (4): 315–29. doi:10.1101/gr.7.4.315. PMID 9110171.
- Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
- Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kim JH, You KR, Kim IH, et al. (2004). "Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma". Hepatology. 39 (1): 129–38. doi:10.1002/hep.20017. PMID 14752831. S2CID 36029858.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Vanjski linkovi
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