RPS4X

RPS4X
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4UG0, 4V6X, 5A2Q, 3J7R, 3J7P
Identifikatori
Aliasi	RPS4X
Vanjski ID-jevi	OMIM: 312760 MGI: 98158 HomoloGene: 90857 GeneCards: RPS4X
Lokacija gena (čovjek) Hrom. Hromosom X[1] Bend Xq13.1 Početak 72,255,679 bp[1] Kraj 72,277,248 bp[1]
Lokacija gena (miš) Hrom. Hromosom X (miš)[2] Bend X D|X 45.2 cM Početak 101,228,547 bp[2] Kraj 101,233,000 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • rRNA binding • structural constituent of ribosome • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK Ćelijska komponenta • citoplazma • polysome • citosol • ribozom • membrana • focal adhesion • intracellular anatomical structure • cytosolic small ribosomal subunit • small ribosomal subunit • cytoplasmic ribonucleoprotein granule • Egzosom • GO:0005578 Vanćelijski matriks • nukleoplazma • ribonukleoprotein • sinapsa Biološki proces • viral transcription • positive regulation of translation • SRP-dependent cotranslational protein targeting to membrane • multicellular organism development • positive regulation of cell population proliferation • translational initiation • Nonsens-posredovano propadanje iRNK • rRNA processing • Biosinteza bjelančevina Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6191	20102
Ensembl	ENSG00000198034	ENSMUSG00000031320
UniProt	P62701	P62702
RefSeq (mRNK)	NM_001007	NM_009094
RefSeq (bjelančevina)	NP_000998	NP_033120
Lokacija (UCSC)	Chr X: 72.26 – 72.28 Mb	Chr X: 101.23 – 101.23 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

X-izoforma 40S ribosomskog proteina S4 je protein koji je kod ljudi kodiran genom RPS4X.^[5][6][7]

Ribosomi, organele koje [kataliziraju sintezu proteina sastoje se od male 40S podjedinice i velike 60S podjedinice. Zajedno, ove podjedinice sastoje se od četiri tipa molekula RNK i približno 80 strukturno različitih proteina. Ovaj gen kodira ribosomski protein S4, komponentu 40S podjedinice. Ribosomski protein S4 jedini je ribosomski protein za koji je poznato da ga kodira više od jednog gena: ovaj gen i onaj za ribosomski protein S4, Y-vezani (RPS4Y). Dvije izoforme koje kodiraju ovi geni nisu identične, ali su funkcijski ekvivalenti. Ribosomski protein S4 pripada porodici ribosomskih proteina S4E. Ovaj gen nije podložan X-inaktivaciji. Sugerira se da haploinsuficijencija gena ribosomskog proteina S4 ima ulogu u pojavi Turnerovog sindroma; međutim, ova hipoteza pokazala se kao kontroverzna. Kao što je uobičajreno za gene koji kodiraju ribosomske proteine, postoji više obrađenih pseudogena ovog gena raspršenih širom genoma.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000198034 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031320 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watanabe M, Furuno N, Goebl M, Go M, Miyauchi K, Sekiguchi T, Basilico C, Nishimito T (Apr 1992). "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene". J Cell Sci. 100 (1): 35–43. PMID 1795030.
6. Zinn AR, Alagappan RK, Brown LG, Wool I, Page DC (Apr 1994). "Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes". Mol Cell Biol. 14 (4): 2485–92. doi:10.1128/mcb.14.4.2485. PMC 358616. PMID 8139551.
7. "Entrez Gene: RPS4X ribosomal protein S4, X-linked".

Dopunska literatura

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• Geerkens C, Just W, Held KR, Vogel W (1996). "Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X". Hum. Genet. 97 (1): 39–44. doi:10.1007/bf00218830. PMID 8557258.
• Vladimirov SN; Ivanov AV; Karpova GG; et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–149. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
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• Andersen JS; Lyon CE; Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–396. doi:10.1093/molbev/msh027. PMID 14660691.
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