ABL2

ABL2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH
Dynodwyr
Cyfenwau	ABL2, ABLL, ARG, ABL proto-oncogene 2, non-receptor tyrosine kinase
Dynodwyr allanol	OMIM: 164690 HomoloGene: 5278 GeneCards: ABL2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • actin monomer binding; • manganese ion binding; • non-membrane spanning protein tyrosine kinase activity; • metal ion binding; • kinase activity; • actin filament binding; • GO:0001948, GO:0016582 protein binding; • signaling receptor binding; • ATP binding; • magnesium ion binding; • protein tyrosine kinase activity; • phosphotyrosine residue binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • extrinsic component of cytoplasmic side of plasma membrane; • actin cytoskeleton; • Cytosgerbwd;
Prosesau biolegol	• cellular response to retinoic acid; • regulation of actin cytoskeleton reorganization; • phosphorylation; • positive regulation of phospholipase C activity; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of cytosolic calcium ion concentration; • GO:1900490 positive regulation of oxidoreductase activity; • regulation of cell motility; • protein phosphorylation; • cell adhesion; • regulation of cell population proliferation; • positive regulation of neuron projection development; • peptidyl-tyrosine autophosphorylation; • peptidyl-tyrosine phosphorylation; • innate immune response; • GO:0072468 signal transduction; • regulation of autophagy; • regulation of endocytosis; • regulation of cell adhesion; • cell differentiation; • negative regulation of Rho protein signal transduction; • exploration behavior;
	Sources:Amigo / QuickGO
Orthologau
	27
	n/a
	ENSG00000143322
	n/a
	P42684
	n/a
NM_001136000; NM_001136001; NM_001168236; NM_001168237; NM_001168238;
	NM_001168239; NM_005158; NM_007314
	n/a
NP_001129472; NP_001129473; NP_001161708; NP_001161709; NP_001161710;
	NP_001161711; NP_005149; NP_009298
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ABL2 yw ABL2 a elwir hefyd yn ABL proto-oncogene 2, non-receptor tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q25.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ABL2.

ARG
ABLL

Llyfryddiaeth

"One isoform of Arg/Abl2 tyrosine kinase is nuclear and the other seven cytosolic isoforms differently modulate cell morphology, motility and the cytoskeleton. ". Exp Cell Res. 2013. PMID 23707396.
"Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. ". Oncogene. 2013. PMID 22777352.
"Knockout mutation of p27-p55 operon severely reduces replication of Mycobacterium bovis in a macrophagic cell line and survival in a mouse model of infection. ". Virulence. 2011. PMID 21543883.
"Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS. ". Blood. 2010. PMID 20448119.
"NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens.". Proteins. 2010. PMID 20077570.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ABL2 - Cronfa NCBI

[1]

[2]