ACTB

ACTB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3BYH, 3D2U, 3J82, 3LUE
Dynodwyr
Cyfenwau	ACTB, BRWS1, PS1TP5BP1, Beta-actin, actin, beta, actin beta
Dynodwyr allanol	OMIM: 102630 HomoloGene: 110648 GeneCards: ACTB
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • nucleotide binding; • nitric-oxide synthase binding; • Tat protein binding; • structural constituent of cytoskeleton; • GO:0001948, GO:0016582 protein binding; • kinesin binding; • identical protein binding; • nucleosomal DNA binding; • ATP binding;
Cydrannau o'r gell	• cytoplasm; • blood microparticle; • bilen; • focal adhesion; • NuA4 histone acetyltransferase complex; • Cellbilen; • nucleoplasm; • cytoplasmic ribonucleoprotein granule; • extracellular exosome; • Cytosgerbwd; • dense body; • cortical cytoskeleton; • cytosol; • myelin sheath; • extracellular space;
Prosesau biolegol	• epigenetic maintenance of chromatin in transcription-competent conformation; • substantia nigra development; • Fc-gamma receptor signaling pathway involved in phagocytosis; • ephrin receptor signaling pathway; • retina homeostasis; • vascular endothelial growth factor receptor signaling pathway; • platelet aggregation; • cell junction assembly; • cytoskeleton organization; • protein deubiquitination; • membrane organization;
	Sources:Amigo / QuickGO
Orthologau
	60
	n/a
	ENSG00000075624
	n/a
	P60709
	n/a
	NM_001101
	n/a
	NP_001092
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ACTB yw ACTB a elwir hefyd yn Actin, cytoplasmic 1 ac Actin beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ACTB.

BRWS1
PS1TP5BP1

Llyfryddiaeth

"ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder. ". Am J Hum Genet. 2017. PMID 29220674.
"ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation. ". J Cell Biol. 2017. PMID 29150539.
"7p22.1 microduplication syndrome: Refinement of the critical region. ". Eur J Med Genet. 2017. PMID 27866048.
"7p22.1 microdeletions involving ACTB associated with developmental delay, short stature, and microcephaly. ". Eur J Med Genet. 2016. PMID 27633570.
"Baraitser-Winter cerebrofrontofacial syndrome.". Clin Genet. 2017. PMID 27625340.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ACTB - Cronfa NCBI

[1]

[2]