ADAR

ADAR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1QBJ, 1QGP, 1XMK, 2ACJ, 2GXB, 2L54, 2MDR, 3F21, 3F22, 3F23, 3IRQ, 3IRR
Dynodwyr
Cyfenwau	ADAR, ADAR1, ADAR2, ADAR3, ADARB1, ADARB2, ADAR1p150, ADAR1p110, IFI-4, DSH, P136, adenosine deaminase RNA specific, DRADA, IFI4, AGS6, G1P1, K88DSRBP, DSRAD
Dynodwyr allanol	OMIM: 146920 HomoloGene: 9281 GeneCards: ADAR
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • metal ion binding; • double-stranded RNA adenosine deaminase activity; • adenosine deaminase activity; • GO:0001948, GO:0016582 protein binding; • hydrolase activity; • RNA binding; • double-stranded RNA binding; • tRNA-specific adenosine deaminase activity;
Cydrannau o'r gell	• cytoplasm; • bilen; • supraspliceosomal complex; • nucleoplasm; • nucleolus; • cnewyllyn cell;
Prosesau biolegol	• hematopoietic stem cell homeostasis; • cellular response to virus; • GO:0033168, GO:0036404, GO:1902360 RNA processing; • protein import into nucleus; • immune system process; • negative regulation of type I interferon-mediated signaling pathway; • mRNA processing; • response to virus; • base conversion or substitution editing; • negative regulation of apoptotic process; • in utero embryonic development; • pre-miRNA processing; • negative regulation of viral genome replication; • defense response to virus; • type I interferon signaling pathway; • osteoblast differentiation; • hematopoietic progenitor cell differentiation; • protein export from nucleus; • response to interferon-alpha; • negative regulation of protein kinase activity by regulation of protein phosphorylation; • erythrocyte differentiation; • somatic diversification of immune receptors via somatic mutation; • definitive hemopoiesis; • positive regulation of viral genome replication; • negative regulation of RNA interference; • gene silencing; • innate immune response; • adenosine to inosine editing; • production of miRNAs involved in gene silencing by miRNA;
	Sources:Amigo / QuickGO
Orthologau
	103
	n/a
	ENSG00000160710
	n/a
	P55265
	n/a
NM_001025107; NM_001111; NM_001193495; NM_015840; NM_015841;
	NM_001365045; NM_001365046; NM_001365047; NM_001365048; NM_001365049
	n/a
	NP_001020278; NP_001102; NP_001180424; NP_056655; NP_056656
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAR yw ADAR a elwir hefyd yn Double-stranded RNA-specific adenosine deaminase ac Adenosine deaminase, RNA specific (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADAR.

DSH
AGS6
G1P1
IFI4
P136
ADAR1
DRADA
DSRAD
IFI-4
K88DSRBP

Llyfryddiaeth

"ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer. ". Tumour Biol. 2017. PMID 29022489.
"RNA editing is induced by type I interferon in esophageal squamous cell carcinoma. ". Tumour Biol. 2017. PMID 28714361.
"Assessing the potential function of ADAR1 in virus-associated sepsis. ". Front Biosci (Landmark Ed). 2017. PMID 28199207.
"ADAR1 overexpression is associated with cervical cancer progression and angiogenesis. ". Diagn Pathol. 2017. PMID 28109322.
"Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases.". Genes (Basel). 2016. PMID 27999332.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ADAR - Cronfa NCBI

[1]

[2]