ADCYAP1

ADCYAP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1GEA, 2D2P, 2JOD
Dynodwyr
Cyfenwau	ADCYAP1, PACAP, adenylate cyclase activating polypeptide 1
Dynodwyr allanol	OMIM: 102980 HomoloGene: 869 GeneCards: ADCYAP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• pituitary adenylate cyclase activating polypeptide activity; • hormone activity; • peptide hormone receptor binding; • GO:0001948, GO:0016582 protein binding; • pituitary adenylate cyclase-activating polypeptide receptor binding; • neuropeptide hormone activity; • signaling receptor binding;
Cydrannau o'r gell	• intracellular anatomical structure; • extracellular region; • terminal bouton; • extracellular space; • neuron projection; • perikaryon; • cell body fiber;
Prosesau biolegol	• histamine secretion; • pituitary gland development; • regulation of G protein-coupled receptor signaling pathway; • negative regulation of glial cell proliferation; • female pregnancy; • cell-cell signaling; • negative regulation of cell cycle; • negative regulation of muscle cell apoptotic process; • behavioral fear response; • nervous system development; • activation of adenylate cyclase activity; • regulation of protein localization; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • ATP metabolic process; • negative regulation of acute inflammatory response to non-antigenic stimulus; • regulation of oligodendrocyte progenitor proliferation; • cellular response to glucocorticoid stimulus; • GO:1901313 positive regulation of gene expression; • GO:0034259 negative regulation of GTPase activity; • positive regulation of synaptic transmission, glutamatergic; • positive regulation of chemokine (C-C motif) ligand 5 production; • regulation of postsynaptic membrane potential; • positive regulation of cell population proliferation; • negative regulation of potassium ion transport; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of interleukin-6 production; • positive regulation of neuron projection development; • response to starvation; • ovarian follicle development; • sensory perception of pain; • response to ethanol; • negative regulation of acute inflammatory response to antigenic stimulus; • neuropeptide signaling pathway; • neuron projection development; • cAMP-mediated signaling; • positive regulation of somatostatin secretion; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of protein kinase activity; • regulation of protein phosphorylation; • positive regulation of cytosolic calcium ion concentration; • insulin secretion; • positive regulation of growth hormone secretion; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of cAMP-mediated signaling; • brain development; • camera-type eye development; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologau
	116
	n/a
	ENSG00000141433
	n/a
	P18509
	n/a
	NM_001099733; NM_001117
	n/a
	NP_001093203; NP_001108
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADCYAP1 yw ADCYAP1 a elwir hefyd yn Adenylate cyclase activating polypeptide 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18p11.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADCYAP1.

PACAP

Llyfryddiaeth

"A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants. ". J Headache Pain. 2016. PMID 27957625.
"No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine. ". Headache. 2016. PMID 27634731.
"Release of PACAP-38 in episodic cluster headache patients - an exploratory study. ". J Headache Pain. 2016. PMID 27475101.
"Pleiotropic and retinoprotective functions of PACAP. ". Anat Sci Int. 2016. PMID 27324639.
"Interictal plasma pituitary adenylate cyclase-activating polypeptide levels are decreased in migraineurs but remain unchanged in patients with tension-type headache.". Clin Chim Acta. 2015. PMID 26296898.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ADCYAP1 - Cronfa NCBI

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[2]