ADRB2

ADRB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4QKX, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 5D5A, 5D5B, 5JQH
Dynodwyr
Cyfenwau	ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, adrenoceptor beta 2
Dynodwyr allanol	OMIM: 109690 HomoloGene: 30948 GeneCards: ADRB2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• adenylate cyclase binding; • adrenergic receptor activity; • beta2-adrenergic receptor activity; • enzyme binding; • protein homodimerization activity; • potassium channel regulator activity; • GO:0001948, GO:0016582 protein binding; • G protein-coupled receptor activity; • signal transducer activity; • norepinephrine binding; • epinephrine binding; • amyloid-beta binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• endosome; • bilen; • cnewyllyn cell; • apical plasma membrane; • lysosome; • integral component of membrane; • receptor complex; • Cellbilen; • early endosome; • integral component of plasma membrane; • endosome membrane; • clathrin-coated vesicle membrane;
Prosesau biolegol	• positive regulation of autophagosome maturation; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • regulation of sodium ion transport; • endosome to lysosome transport; • receptor-mediated endocytosis; • cell surface receptor signaling pathway; • regulation of systemic arterial blood pressure by norepinephrine-epinephrine; • negative regulation of smooth muscle contraction; • regulation of smooth muscle contraction; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • bone resorption; • adenylate cyclase-activating adrenergic receptor signaling pathway; • heat generation; • desensitization of G protein-coupled receptor signaling pathway by arrestin; • positive regulation of MAPK cascade; • G protein-coupled receptor signaling pathway; • positive regulation of bone mineralization; • activation of adenylate cyclase activity; • brown fat cell differentiation; • activation of transmembrane receptor protein tyrosine kinase activity; • positive regulation of protein ubiquitination; • negative regulation of multicellular organism growth; • cell-cell signaling; • diet induced thermogenesis; • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; • positive regulation of lipophagy; • response to cold; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0072468 signal transduction; • protein deubiquitination; • membrane organization; • adrenergic receptor signaling pathway; • blood vessel diameter maintenance; • positive regulation of protein kinase A signaling; • positive regulation of mini excitatory postsynaptic potential; • positive regulation of protein serine/threonine kinase activity; • positive regulation of cold-induced thermogenesis; • cellular response to amyloid-beta; • response to psychosocial stress; • positive regulation of cAMP-dependent protein kinase activity; • positive regulation of AMPA receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	154
	n/a
	ENSG00000169252
	n/a
	P07550
	n/a
	NM_000024
	n/a
	NP_000015
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADRB2 yw ADRB2 a elwir hefyd yn Adrenoceptor beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADRB2.

BAR
B2AR
ADRBR
ADRB2R
BETA2AR

Llyfryddiaeth

"Association Between ADRB2 Genetic Polymorphisms and the Risk of Chronic Obstructive Pulmonary Disease: A Case-Control Study in a Chinese Population. ". Genet Test Mol Biomarkers. 2017. PMID 28753063.
"Single-molecule analysis of ligand efficacy in β2AR-G-protein activation. ". Nature. 2017. PMID 28607487.
"N-glycosylation of the β2 adrenergic receptor regulates receptor function by modulating dimerization. ". FEBS J. 2017. PMID 28467637.
"ADRB2 polymorphisms and dyslipidemia risk in Chinese hypertensive patients. ". Clin Exp Hypertens. 2017. PMID 28287890.
"B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma.". World J Gastroenterol. 2017. PMID 28275305.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ADRB2 - Cronfa NCBI

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[2]