AKR1C4

AKR1C4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2FVL
Dynodwyr
Cyfenwau	AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1, member C4, aldo-keto reductase family 1 member C4
Dynodwyr allanol	OMIM: 600451 HomoloGene: 84695 GeneCards: AKR1C4
EC number	1.1.1.225
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• retinal dehydrogenase activity; • aldo-keto reductase (NADP) activity; • bile acid transmembrane transporter activity; • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; • chlordecone reductase activity; • electron transfer activity; • oxidoreductase activity; • androsterone dehydrogenase activity; • alditol:NADP+ 1-oxidoreductase activity; • alcohol dehydrogenase (NADP+) activity; • steroid dehydrogenase activity; • ketosteroid monooxygenase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • extracellular exosome;
Prosesau biolegol	• cellular response to jasmonic acid stimulus; • steroid metabolic process; • daunorubicin metabolic process; • doxorubicin metabolic process; • androgen metabolic process; • retinoid metabolic process; • bile acid and bile salt transport; • bile acid biosynthetic process; • electron transport chain; • prostaglandin metabolic process; • progesterone metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	1109
	n/a
	ENSG00000198610
	n/a
	P17516
	n/a
	NM_001818
	n/a
	NP_001809
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1C4 yw AKR1C4 a elwir hefyd yn Aldo-keto reductase family 1 member C4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p15.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1C4.

C11
CDR
DD4
CHDR
DD-4
HAKRA
3-alpha-HSD

Llyfryddiaeth

"AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder. ". J Affect Disord. 2011. PMID 21570127.
"An estrogen metabolism-related polymorphism of the 17-alpha HSD gene is associated with perimenopausal body mass index. ". Fertil Steril. 2007. PMID 17207797.
"Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. ". Mol Psychiatry. 2006. PMID 16344854.
"Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha. ". Biochem J. 2001. PMID 11284743.
"Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.". J Clin Endocrinol Metab. 2001. PMID 11158055.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AKR1C4 - Cronfa NCBI

[1]

[2]