AKR7A2

AKR7A2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2BP1
Dynodwyr
Cyfenwau	AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7, aldo-keto reductase family 7, member A2, aldo-keto reductase family 7 member A2
Dynodwyr allanol	OMIM: 603418 HomoloGene: 2737 GeneCards: AKR7A2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• alditol:NADP+ 1-oxidoreductase activity; • electron transfer activity; • oxidoreductase activity; • phenanthrene-9,10-epoxide hydrolase activity; • aldo-keto reductase (NADP) activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • Golgi apparatus; • extracellular exosome; • cytosol;
Prosesau biolegol	• xenobiotic metabolic process; • cellular aldehyde metabolic process; • daunorubicin metabolic process; • doxorubicin metabolic process; • carbohydrate metabolic process; • electron transport chain;
	Sources:Amigo / QuickGO
Orthologau
	8574
	n/a
	ENSG00000053371
	n/a
	O43488
	n/a
	NM_003689; NM_001320979
	n/a
	NP_001307908; NP_003680
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR7A2 yw AKR7A2 a elwir hefyd yn Aflatoxin B1 aldehyde reductase member 2 ac Aldo-keto reductase family 7 member A2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR7A2.

AFAR
AKR7
AFAR1
AFB1-AR1

Llyfryddiaeth

"Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells. ". Cancer Res. 1998. PMID 9823300.
"Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2. ". Chem Biol Interact. 2015. PMID 25451587.
"The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner. ". Cell Mol Biol Lett. 2016. PMID 28536627.
"Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells. ". Cancer Lett. 2008. PMID 18752886.
"Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2.". J Biol Chem. 2007. PMID 17591773.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AKR7A2 - Cronfa NCBI

[1]

[2]