AKT2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/6/60/Protein_AKT2_PDB_1gzk.png/250px-Protein_AKT2_PDB_1gzk.png) |
Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Rhestr o ddynodwyr PDB |
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1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D |
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Dynodwyr |
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Cyfenwau | AKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2 |
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Dynodwyr allanol | OMIM: 164731 HomoloGene: 48773 GeneCards: AKT2 |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn AKT2 yw AKT2 a elwir hefyd yn RAC-beta serine/threonine-protein kinase ac AKT serine/threonine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKT2.
- PKBB
- PRKBB
- HIHGHH
- PKBBETA
- RAC-BETA
- "Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia. ". J Clin Endocrinol Metab. 2017. PMID 28541532.
- "A Low-Frequency Inactivating AKT2Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. ". Diabetes. 2017. PMID 28341696.
- "A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain. ". PLoS One. 2016. PMID 28036396.
- "Hypermethylation of AKT2 gene is associated with neural-tube defects in fetus. ". Placenta. 2016. PMID 27871477.
- "Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation.". Sci Rep. 2015. PMID 26234648.