ANXA5

ANXA5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2XO3, 1ANW, 1ANX, 1AVH, 1AVR, 1HAK, 1HVD, 1HVE, 1HVF, 1HVG, 1SAV, 2XO2
Dynodwyr
Cyfenwau	ANXA5, ANX5, ENX2, HEL-S-7, PP4, RPRGL3, annexin A5, CPB-I, VAC-alph
Dynodwyr allanol	OMIM: 131230 HomoloGene: 20312 GeneCards: ANXA5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phospholipase inhibitor activity; • calcium ion binding; • GO:0001948, GO:0016582 protein binding; • calcium-dependent phospholipid binding; • phospholipid binding; • P-type calcium transporter activity; • heparin binding; • peptide hormone binding; • receptor tyrosine kinase binding; • GO:0032947 molecular adaptor activity;
Cydrannau o'r gell	• bilen; • focal adhesion; • intracellular anatomical structure; • endothelial microparticle; • extracellular exosome; • external side of plasma membrane; • extracellular region; • cytoplasm; • cytosol; • collagen-containing extracellular matrix;
Prosesau biolegol	• hemostasis; • negative regulation of coagulation; • blood coagulation; • negative regulation of apoptotic process; • response to organic substance; • GO:0072468 signal transduction; • GO:0048553 negative regulation of catalytic activity; • platelet degranulation; • negative regulation of blood coagulation; • positive regulation of apoptotic process; • protein homooligomerization; • negative regulation of sequestering of calcium ion; • response to calcium ion; • calcium ion transmembrane transport; • cellular response to lead ion; • response to thyroid hormone; • cellular response to gonadotropin-releasing hormone; • regulation of flagellated sperm motility; • negative regulation of prolactin secretion;
	Sources:Amigo / QuickGO
Orthologau
	308
	n/a
	ENSG00000164111
	n/a
	P08758
	n/a
	NM_001154
	n/a
	NP_001145
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ANXA5 yw ANXA5 a elwir hefyd yn Annexin A5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q27.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ANXA5.

PP4
ANX5
ENX2
RPRGL3
HEL-S-7

Llyfryddiaeth

"The association between annexin A5 (ANXA5) gene polymorphism and left ventricular hypertrophy (LVH) in Chinese endogenous hypertension patients. ". Medicine (Baltimore). 2017. PMID 29095261.
"Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition. ". Diab Vasc Dis Res. 2017. PMID 28592134.
"Functional characterization of annexin A5 gene promoter allelic variants. ". Thromb Res. 2016. PMID 27318245.
"Membrane repair of human skeletal muscle cells requires Annexin-A5. ". Biochim Biophys Acta. 2016. PMID 27286750.
"Investigation of the Annexin A5 M2 haplotype in 500 white European couples who have experienced recurrent spontaneous abortion.". Reprod Biomed Online. 2015. PMID 26371709.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ANXA5 - Cronfa NCBI

[1]

[2]