AP2A2

AP2A2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
Dynodwyr
Cyfenwau	AP2A2, ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2
Dynodwyr allanol	OMIM: 607242 HomoloGene: 5335 GeneCards: AP2A2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• clathrin adaptor activity; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • lipid binding; • protein domain specific binding; • disordered domain specific binding; • molecular function;
Cydrannau o'r gell	• endocytic vesicle membrane; • cytosol; • clathrin-coated endocytic vesicle membrane; • bilen; • Cellbilen; • endolysosome membrane; • membrane coat; • clathrin-coated pit; • AP-2 adaptor complex; • clathrin adaptor complex; • secretory granule membrane; • GO:0016023 cytoplasmic vesicle; • ficolin-1-rich granule membrane; • clathrin-coated endocytic vesicle;
Prosesau biolegol	• endocytosis; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • ephrin receptor signaling pathway; • GO:0019049, GO:0030683 mitigation of host defenses by virus; • clathrin-dependent endocytosis; • protein transport; • intracellular protein transport; • vesicle-mediated transport; • microtubule-based movement; • Wnt signaling pathway, planar cell polarity pathway; • neutrophil degranulation; • membrane organization; • low-density lipoprotein particle receptor catabolic process; • low-density lipoprotein particle clearance; • GO:0015915 transport;
	Sources:Amigo / QuickGO
Orthologau
	161
	n/a
	ENSG00000281385; ENSG00000280759; ENSG00000183020
	n/a
	O94973
	n/a
	NM_001242837; NM_012305
	n/a
	NP_001229766; NP_036437
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AP2A2 yw AP2A2 a elwir hefyd yn AP-2 complex subunit alpha-2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.5.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AP2A2.

HIP9
HYPJ
ADTAB
HIP-9
CLAPA2

Llyfryddiaeth

"Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2. ". J Cell Biol. 2017. PMID 28003333.
"HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin. ". J Biol Chem. 2009. PMID 19359243.
"Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene. ". Gene. 2002. PMID 12036598.
"The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. ". J Biol Chem. 1996. PMID 8662627.
"Interaction of Shc with adaptor protein adaptins.". J Biol Chem. 1996. PMID 8617812.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AP2A2 - Cronfa NCBI

[1]

[2]