AP2B1

AP2B1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1E42, 2G30, 2IV8, 2IV9, 2JKR, 2JKT, 2VGL, 2XA7, 4UQI
Dynodwyr
Cyfenwau	AP2B1, ADTB2, AP105B, AP2-BETA, CLAPB1, adaptor related protein complex 2 beta 1 subunit, adaptor related protein complex 2 subunit beta 1
Dynodwyr allanol	OMIM: 601025 HomoloGene: 68176 GeneCards: AP2B1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• clathrin adaptor activity; • GO:0032403 protein-containing complex binding; • clathrin binding; • signal sequence binding; • GO:0001948, GO:0016582 protein binding; • cargo receptor activity;
Cydrannau o'r gell	• endocytic vesicle membrane; • cytosol; • clathrin-coated endocytic vesicle membrane; • bilen; • clathrin coat; • Cellbilen; • trans-Golgi network; • endolysosome membrane; • membrane coat; • clathrin-coated pit; • clathrin adaptor complex; • AP-2 adaptor complex; • clathrin-coated endocytic vesicle; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• cardiac septum development; • endocytosis; • ventricular septum development; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • ephrin receptor signaling pathway; • GO:0019049, GO:0030683 mitigation of host defenses by virus; • coronary vasculature development; • aorta development; • heart development; • clathrin-dependent endocytosis; • clathrin coat assembly; • protein transport; • intracellular protein transport; • vesicle-mediated transport; • microtubule-based movement; • Wnt signaling pathway, planar cell polarity pathway; • membrane organization; • neurotransmitter receptor internalization; • low-density lipoprotein particle receptor catabolic process; • low-density lipoprotein particle clearance; • GO:0015915 transport; • positive regulation of endocytosis; • postsynaptic neurotransmitter receptor internalization; • negative regulation of neuron death; • positive regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologau
	163
	n/a
	ENSG00000006125
	n/a
	P63010
	n/a
	NM_001030006; NM_001282
	n/a
	NP_001025177; NP_001273
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AP2B1 yw AP2B1 a elwir hefyd yn AP-2 complex subunit beta ac Adaptor related protein complex 2 beta 1 subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AP2B1.

ADTB2
AP105B
CLAPB1
AP2-BETA

Llyfryddiaeth

"Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. ". Mol Cell Biol. 2006. PMID 16581796.
"Expression of a novel beta adaptin subunit mRNA splice variant in human testes. ". Asian J Androl. 2005. PMID 15897975.
"The structure and function of the beta 2-adaptin appendage domain. ". EMBO J. 2000. PMID 10944104.
"Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch. ". Science. 2014. PMID 25061211.
"A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.". Cell. 2010. PMID 20603002.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AP2B1 - Cronfa NCBI

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[2]