ARAF

ARAF
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1WXM, 2MSE
Dynodwyr
Cyfenwau	ARAF, A-Raf proto-oncogene, serine/threonine kinase, A-RAF, ARAF1, PKS2, RAFA1, Serine/threonine-protein kinase A-Raf
Dynodwyr allanol	OMIM: 311010 HomoloGene: 1249 GeneCards: ARAF
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • MAP kinase kinase kinase activity; • mitogen-activated protein kinase kinase binding;
Cydrannau o'r gell	• mitocondria; • cytosol; • cydran cellog;
Prosesau biolegol	• GO:0007243 intracellular signal transduction; • regulation of TOR signaling; • phosphorylation; • negative regulation of apoptotic process; • positive regulation of peptidyl-serine phosphorylation; • MAPK cascade; • protein phosphorylation; • regulation of proteasomal ubiquitin-dependent protein catabolic process; • GO:0072468 signal transduction; • multicellular organism development; • negative regulation of signal transduction; • cell differentiation; • positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologau
	369
	n/a
	ENSG00000078061
	n/a
	P10398; Q96II5
	n/a
	NM_001256196; NM_001256197; NM_001654
	n/a
	NP_001243125; NP_001243126; NP_001645; NP_001243125.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARAF yw ARAF a elwir hefyd yn A-Raf proto-oncogene, serine/threonine kinase ac ARAF protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARAF.

PKS2
A-RAF
ARAF1
RAFA1

Llyfryddiaeth

"A-Raf: A new star of the family of raf kinases. ". Crit Rev Biochem Mol Biol. 2015. PMID 26508523.
"Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. ". Sci Signal. 2014. PMID 25097033.
"Somatic activating ARAF mutations in Langerhans cell histiocytosis. ". Blood. 2014. PMID 24652991.
"Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites. ". J Biol Chem. 2008. PMID 18662992.
"Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity.". Biochemistry. 2005. PMID 15736953.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ARAF - Cronfa NCBI

[1]

[2]