ARHGAP35

ARHGAP35
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2K85, 3C5H, 3FK2
Dynodwyr
Cyfenwau	ARHGAP35, GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP, Rho GTPase activating protein 35
Dynodwyr allanol	OMIM: 605277 HomoloGene: 35136 GeneCards: ARHGAP35
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001106 transcription corepressor activity; • GTP binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • phospholipid binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • GO:0006184 GTPase activity; • nucleotide binding; • lipid binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • actin cytoskeleton; • cnewyllyn cell; • Cytosgerbwd; • cell projection; • Cellbilen; • bilen; • ciliary basal body;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • negative regulation of Rho protein signal transduction; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • neural tube closure; • regulation of cell shape; • forebrain development; • camera-type eye development; • GO:0045996 negative regulation of transcription, DNA-templated; • regulation of small GTPase mediated signal transduction; • GO:0072468 signal transduction; • negative regulation of vascular permeability; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • axon guidance; • axonal fasciculation; • regulation of actin polymerization or depolymerization; • positive regulation of neuron projection development; • cell migration; • central nervous system neuron axonogenesis; • mammary gland development; • establishment or maintenance of actin cytoskeleton polarity; • cellular response to extracellular stimulus; • regulation of actin cytoskeleton organization; • wound healing, spreading of cells; • positive regulation of cilium assembly; • regulation of axonogenesis; • neuron projection guidance;
	Sources:Amigo / QuickGO
Orthologau
	2909
	n/a
	ENSG00000160007
	n/a
	Q9NRY4
	n/a
	NM_004491; NM_024342
	n/a
	NP_004482
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGAP35 yw ARHGAP35 a elwir hefyd yn Rho GTPase activating protein 35 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGAP35.

GRF-1
GRLF1
P190A
P190-A
p190RhoGAP
p190ARhoGAP

Llyfryddiaeth

"Glucocorticoid receptor DNA binding factor 1 expression and osteosarcoma prognosis. ". Tumour Biol. 2014. PMID 25185653.
"Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis. ". Biomed Res Int. 2014. PMID 25136583.
"p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells. ". Int J Oncol. 2013. PMID 24043274.
"Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesis. ". J Biol Chem. 2010. PMID 20534586.
"p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.". Gene. 2000. PMID 11054565.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ARHGAP35 - Cronfa NCBI

[1]

[2]