ATF2 |
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Dynodwyr |
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Cyfenwau | ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7, activating transcription factor 2 |
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Dynodwyr allanol | OMIM: 123811 HomoloGene: 31061 GeneCards: ATF2 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • transferase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • cAMP response element binding protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • chromatin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein kinase binding • cAMP response element binding • histone acetyltransferase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • protein heterodimerization activity
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Cydrannau o'r gell | • cytoplasm • bilen • nucleoplasm • mitochondrial outer membrane • mitocondria • cnewyllyn cell • site of double-strand break
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Prosesau biolegol | • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • mitotic intra-S DNA damage checkpoint signaling • outflow tract morphogenesis • response to water deprivation • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • positive regulation of transforming growth factor beta2 production • transcription, DNA-templated • cellular response to DNA damage stimulus • response to osmotic stress • positive regulation of neuron apoptotic process • regulation of DNA-binding transcription factor activity • positive regulation of mitochondrial membrane permeability involved in apoptotic process • negative regulation of epithelial cell proliferation • adipose tissue development • fat cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • amelogenesis • histone acetylation • positive regulation of cardiac muscle myoblast proliferation • GO:1901313 positive regulation of gene expression • negative regulation of angiogenesis
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn ATF2 yw ATF2 a elwir hefyd yn Activating transcription factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATF2.
- HB16
- CREB2
- TREB7
- CREB-2
- CRE-BP1
- "Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis. ". J Biol Chem. 2017. PMID 28904175.
- "ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease. ". Pharmacol Res. 2017. PMID 28212892.
- "ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma. ". J Exp Clin Cancer Res. 2016. PMID 27377902.
- "ATF-2 immunoreactivity in post-mitotic and terminally differentiated human odontoblasts. ". Med Mol Morphol. 2015. PMID 25417007.
- "Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.". Breast Cancer Res Treat. 2014. PMID 25141981.