ATOX1

ATOX1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FE0, 1FE4, 1FEE, 1TL4, 1TL5, 2K1R, 2LQ9, 3CJK, 3IWL, 3IWX, 4QOT, 4YDX, 4YEA
Dynodwyr
Cyfenwau	ATOX1, ATX1, HAH1, antioxidant 1 copper chaperone
Dynodwyr allanol	OMIM: 602270 HomoloGene: 2984 GeneCards: ATOX1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• copper ion transmembrane transporter activity; • metallochaperone activity; • copper ion binding; • GO:0001948, GO:0016582 protein binding; • copper chaperone activity; • copper-dependent protein binding; • metal ion binding; • ATPase binding;
Cydrannau o'r gell	• cytosol;
Prosesau biolegol	• GO:0070839 metal ion transport; • copper ion transport; • cludo ïon; • protein maturation by copper ion transfer; • copper ion transmembrane transport; • cellular copper ion homeostasis; • GO:0001306 response to oxidative stress; • negative regulation of apoptotic process; • copper ion export;
	Sources:Amigo / QuickGO
Orthologau
	475
	n/a
	ENSG00000177556
	n/a
	O00244
	n/a
	NM_004045
	n/a
	NP_004036
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATOX1 yw ATOX1 a elwir hefyd yn Antioxidant 1 copper chaperone (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATOX1.

ATX1
HAH1

Llyfryddiaeth

"Binding of Copper and Cisplatin to Atox1 Is Mediated by Glutathione through the Formation of Metal-Sulfur Clusters. ". Biochemistry. 2017. PMID 28549213.
"The structural flexibility of the human copper chaperone Atox1: Insights from combined pulsed EPR studies and computations. ". Protein Sci. 2017. PMID 28543811.
"Thiol-based copper handling by the copper chaperone Atox1. ". IUBMB Life. 2017. PMID 28294521.
"Copper chaperone Atox1 plays role in breast cancer cell migration. ". Biochem Biophys Res Commun. 2017. PMID 28027931.
"ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs.". J Inorg Biochem. 2016. PMID 26784148.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ATOX1 - Cronfa NCBI

[1]

[2]