B3GAT3

B3GAT3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FGG, 1KWS, 3CU0
Dynodwyr
Cyfenwau	B3GAT3, GLCATI, glcUAT-I, JDSCD, beta-1,3-glucuronyltransferase 3
Dynodwyr allanol	OMIM: 606374 HomoloGene: 56554 GeneCards: B3GAT3
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein phosphatase activator activity; • glucuronosyltransferase activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;
Cydrannau o'r gell	• integral component of membrane; • Golgi apparatus; • bilen; • cis-Golgi network; • extracellular exosome; • Golgi membrane;
Prosesau biolegol	• positive regulation of intracellular protein transport; • glycosaminoglycan metabolic process; • heparan sulfate proteoglycan biosynthetic process; • GO:0048554 positive regulation of catalytic activity; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • glycosaminoglycan biosynthetic process; • chondroitin sulfate proteoglycan biosynthetic process; • dermatan sulfate proteoglycan biosynthetic process; • chondroitin sulfate metabolic process; • carbohydrate metabolic process; • regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologau
	26229
	n/a
	ENSG00000149541
	n/a
	O94766
	n/a
	NM_001288721; NM_001288722; NM_001288723; NM_012200
	n/a
	NP_001275650; NP_001275651; NP_001275652; NP_036332
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn B3GAT3 yw B3GAT3 a elwir hefyd yn Beta-1,3-glucuronyltransferase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q12.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn B3GAT3.

JDSCD
GLCATI
glcUAT-I

Llyfryddiaeth

"Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3. ". Hum Genet. 2015. PMID 25893793.
CHST3-Related Skeletal Dysplasia. 1993. PMID 21882400.
"2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. ". J Biol Chem. 2008. PMID 18400750.
"The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif. ". J Biol Chem. 2003. PMID 12794088.
"Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues.". J Biol Chem. 2000. PMID 10842173.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] B3GAT3 - Cronfa NCBI

[1]

[2]