BACH2

BACH2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3OHU, 3OHV
Dynodwyr
Cyfenwau	BACH2, BTBD25, BTB domain and CNC homolog 2, IMD60
Dynodwyr allanol	OMIM: 605394 HomoloGene: 7240 GeneCards: BACH2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0050372 ubiquitin-protein transferase activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • Cul3-RING ubiquitin ligase complex; • cnewyllyn cell; • cytosol;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • transcription, DNA-templated; • protein ubiquitination; • import into nucleus;
	Sources:Amigo / QuickGO
Orthologau
	60468
	n/a
	ENSG00000112182
	n/a
	Q9BYV9
	n/a
	NM_001170794; NM_021813
	n/a
	NP_001164265; NP_068585
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BACH2 yw BACH2 a elwir hefyd yn BTB domain and CNC homolog 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q15.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BACH2.

BTBD25

Llyfryddiaeth

"Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding region. ". J Biochem. 2016. PMID 27206783.
"No association between Bach2 gene polymorphisms with Vogt-Koyanagi-Harada syndrome (VKH) and Behcet's disease (BD) in a Chinese Han population. ". Br J Ophthalmol. 2015. PMID 25873652.
"BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency. ". Nat Immunol. 2017. PMID 28530713.
"Frequent downregulation of BTB and CNC homology 2 expression in Epstein-Barr virus-positive diffuse large B-cell lymphoma. ". Cancer Sci. 2017. PMID 28256087.
"A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans.". J Clin Endocrinol Metab. 2016. PMID 27680876.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BACH2 - Cronfa NCBI

[1]

[2]