BCL2L11

BCL2L11
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1F95, 2K7W, 2NL9, 2V6Q, 2VM6, 2WH6, 2YQ6, 2YQ7, 3D7V, 3FDL, 3IO8, 3IO9, 3KJ0, 3KJ1, 3KJ2, 4A1U, 4A1W, 4B4S, 4D2M, 4QVF, 4UF3, 4YJ4, 4ZIF, 4ZIH, 5AGW, 5AGX, 5C3G
Dynodwyr
Cyfenwau	BCL2L11, BAM, BIM, BOD, BCL2 like 11
Dynodwyr allanol	OMIM: 603827 HomoloGene: 7643 GeneCards: BCL2L11
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • microtubule binding; • dynein complex binding; • protein heterodimerization activity; • protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • intracellular membrane-bounded organelle; • BIM-BCL-2 complex; • mitochondrial outer membrane; • BIM-BCL-xl complex; • cytoplasmic dynein complex; • mitocondria; • microtubule; • endomembrane system; • extrinsic component of membrane; • Bcl-2 family protein complex;
Prosesau biolegol	• leukocyte homeostasis; • regulation of apoptotic process; • positive regulation of protein homooligomerization; • male gonad development; • positive regulation of cell death; • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • B cell apoptotic process; • kidney development; • thymus development; • lymphocyte homeostasis; • positive regulation of apoptotic process by virus; • myeloid cell homeostasis; • post-embryonic animal organ morphogenesis; • ear development; • in utero embryonic development; • B cell homeostasis; • spleen development; • thymocyte apoptotic process; • post-embryonic development; • response to endoplasmic reticulum stress; • mammary gland development; • T cell homeostasis; • odontogenesis of dentin-containing tooth; • positive regulation of IRE1-mediated unfolded protein response; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • tube formation; • brain development; • positive regulation of neuron apoptotic process; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • positive regulation of cell cycle; • positive regulation of mitochondrial membrane permeability involved in apoptotic process; • meiosis I; • spermatogenesis; • intrinsic apoptotic signaling pathway in response to DNA damage; • extrinsic apoptotic signaling pathway in absence of ligand; • positive regulation of apoptotic process; • positive regulation of fibroblast apoptotic process; • developmental pigmentation; • positive regulation of release of cytochrome c from mitochondria; • regulation of developmental pigmentation; • cell-matrix adhesion; • regulation of organ growth; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of intrinsic apoptotic signaling pathway; • apoptotic process involved in embryonic digit morphogenesis; • GO:0097285 apoptotic process; • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • positive regulation of autophagy in response to ER overload; • cellular response to glucocorticoid stimulus; • cellular response to estradiol stimulus; • cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologau
	10018
	n/a
	ENSG00000153094
	n/a
	O43521
	n/a
NM_001204106; NM_001204107; NM_001204108; NM_001204109; NM_001204110;
	NM_001204111; NM_001204112; NM_001204113; NM_006538; NM_138621; NM_138622; NM_138623; NM_138624; NM_138625; NM_138626; NM_138627; NM_207002; NM_207003
	n/a
NP_001191035; NP_001191036; NP_001191037; NP_001191038; NP_001191039;
	NP_001191040; NP_001191041; NP_001191042; NP_006529; NP_619527; NP_619528; NP_619529; NP_619530; NP_619531; NP_619532; NP_619533; NP_996885; NP_996886
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL2L11 yw BCL2L11 a elwir hefyd yn Bcl-2-like protein 11 a BCL2 like 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL2L11.

BAM
BIM
BOD

Llyfryddiaeth

"BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations. ". Oncotarget. 2016. PMID 27926478.
"CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood. ". J Leukoc Biol. 2017. PMID 27630216.
"Bcl-2-like Protein 11 (BIM) Expression Is Associated with Favorable Prognosis for Patients with Cervical Cancer. ". Anticancer Res. 2017. PMID 28870908.
"Lack of association between deletion polymorphism of BIM gene and in vitro drug sensitivity in B-cell precursor acute lymphoblastic leukemia. ". Leuk Res. 2017. PMID 28641145.
"Clinical features of Bim deletion polymorphism and its relation with crizotinib primary resistance in Chinese patients with ALK/ROS1 fusion-positive non-small cell lung cancer.". Cancer. 2017. PMID 28346673.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BCL2L11 - Cronfa NCBI

[1]

[2]