BIRC3

BIRC3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2UVL, 3EB5, 3EB6, 3M0A, 3M0D
Dynodwyr
Cyfenwau	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2, baculoviral IAP repeat containing 3, IAP-1
Dynodwyr allanol	OMIM: 601721 HomoloGene: 899 GeneCards: BIRC3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • cysteine-type endopeptidase inhibitor activity involved in apoptotic process; • GO:0001948, GO:0016582 protein binding; • GO:0050372 ubiquitin-protein transferase activity; • transferase activity; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity;
Cydrannau o'r gell	• cytoplasm; • nucleoplasm; • membrane raft; • cnewyllyn cell; • cytosol; • GO:0009327 protein-containing complex;
Prosesau biolegol	• regulation of apoptotic process; • regulation of nucleotide-binding oligomerization domain containing signaling pathway; • regulation of innate immune response; • regulation of toll-like receptor signaling pathway; • negative regulation of necroptotic process; • inhibition of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of cysteine-type endopeptidase activity; • regulation of RIG-I signaling pathway; • regulation of tumor necrosis factor-mediated signaling pathway; • negative regulation of apoptotic process; • tumor necrosis factor-mediated signaling pathway; • mitotic spindle assembly; • cell surface receptor signaling pathway; • NIK/NF-kappaB signaling; • spermatogenesis; • regulation of inflammatory response; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • I-kappaB kinase/NF-kappaB signaling; • positive regulation of protein ubiquitination; • GO:0097285 apoptotic process; • protein ubiquitination; • protein deubiquitination; • regulation of necroptotic process; • protein heterooligomerization; • MyD88-independent toll-like receptor signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	330
	n/a
	ENSG00000023445
	n/a
	Q13489
	n/a
	NM_001165; NM_182962
	n/a
	NP_001156; NP_892007
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BIRC3 yw BIRC3 a elwir hefyd yn Baculoviral IAP repeat containing 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BIRC3.

AIP1
API2
MIHC
CIAP2
HAIP1
HIAP1
MALT2
RNF49
c-IAP2

Llyfryddiaeth

"cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-κB pathway. ". Cancer Sci. 2017. PMID 28295868.
"BIRC3 single nucleotide polymorphism associate with asthma susceptibility and the abundance of eosinophils and neutrophils. ". J Asthma. 2017. PMID 27304223.
"Helicobacter pyloriEradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis. ". Gut Liver. 2017. PMID 27282269.
"BIRC3 is a novel driver of therapeutic resistance in Glioblastoma. ". Sci Rep. 2016. PMID 26888114.
"Regulation of antiapoptotic and cytoprotective pathways in colonic epithelial cells in ulcerative colitis.". Scand J Gastroenterol. 2015. PMID 26513451.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BIRC3 - Cronfa NCBI

[1]

[2]