BMI1

BMI1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2H0D, 3RPG, 4R8P
Dynodwyr
Cyfenwau	BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
Dynodwyr allanol	OMIM: 164831 HomoloGene: 136787 GeneCards: BMI1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• promoter-specific chromatin binding; • RING-like zinc finger domain binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • zinc ion binding;
Cydrannau o'r gell	• cytoplasm; • ubiquitin ligase complex; • nucleoplasm; • PRC1 complex; • PcG protein complex; • cnewyllyn cell; • cytosol; • nuclear body;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • positive regulation of fibroblast proliferation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • segment specification; • negative regulation of gene expression, epigenetic; • positive regulation of ubiquitin-protein transferase activity; • regulation of gene expression; • histone H2A-K119 monoubiquitination; • negative regulation of G0 to G1 transition; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • hemopoiesis;
	Sources:Amigo / QuickGO
Orthologau
	648
	n/a
	ENSG00000168283
	n/a
	P35226; Q5T8Z6
	n/a
	NM_005180
	n/a
	NP_001190991; NP_005171
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BMI1 yw BMI1 a elwir hefyd yn BMI1 proto-oncogene, polycomb ring finger a Polycomb complex protein BMI-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p12.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BMI1.

PCGF4
RNF51
FLVI2/BMI1
flvi-2/bmi-1

Llyfryddiaeth

"Clinical Significance of Bmi1 Expression in Inflammatory Bowel Disease. ". Oncology. 2017. PMID 29258116.
"O-GlcNAcylation modulates Bmi-1 protein stability and potential oncogenic function in prostate cancer. ". Oncogene. 2017. PMID 28714959.
"Bmi-1 overexpression as an efficient prognostic marker in patients with nonsmall cell lung cancer. ". Medicine (Baltimore). 2017. PMID 28658153.
"Prognostic Significance of BMI-1 But Not MEL-18 Expression in Pulmonary Squamous Cell Carcinoma. ". Anticancer Res. 2017. PMID 28373461.
"Silencing BMI1 radiosensitizes human breast cancer cells by inducing DNA damage and autophagy.". Oncol Rep. 2017. PMID 28260023.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BMI1 - Cronfa NCBI

[1]

[2]