CALCA

CALCA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JXZ,%%s1LS7
Dynodwyr
Cyfenwau	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Dynodwyr allanol	OMIM: 114130 HomoloGene: 88401 GeneCards: CALCA
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hormone activity; • calcitonin receptor binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • signaling receptor binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• cytoplasm; • intracellular anatomical structure; • extracellular region; • axon; • terminal bouton; • soma; • neuron projection; • cnewyllyn cell; • extracellular space;
Prosesau biolegol	• cellular response to nerve growth factor stimulus; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • negative regulation of smooth muscle contraction; • regulation of heart contraction; • monocyte chemotaxis; • negative regulation of blood pressure; • positive regulation of cytosolic calcium ion concentration; • cellular response to tumor necrosis factor; • GO:0010260 heneiddio; • vasodilation; • cellular calcium ion homeostasis; • response to heat; • negative regulation of nervous system process; • positive regulation of ossification; • activation of adenylate cyclase activity; • regulation of heart rate; • detection of temperature stimulus involved in sensory perception of pain; • negative regulation of ossification; • response to pain; • artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; • feeding behavior; • inflammatory response; • neuropeptide signaling pathway; • GO:0045996 negative regulation of transcription, DNA-templated; • activation of protein kinase activity; • embryo implantation; • negative regulation of bone resorption; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • regulation of cytosolic calcium ion concentration; • leukocyte cell-cell adhesion; • G protein-coupled receptor internalization; • positive regulation of interleukin-1 alpha production; • response to yeast; • negative regulation of osteoclast differentiation; • cell-cell signaling; • antibacterial humoral response; • positive regulation of macrophage differentiation; • receptor internalization; • regulation of blood pressure; • protein phosphorylation; • vasculature development; • GO:0051636 defense response to Gram-negative bacterium; • endothelial cell proliferation; • positive regulation of interleukin-8 production; • nervous system process involved in regulation of systemic arterial blood pressure; • negative regulation of calcium ion transport into cytosol; • innate immune response; • endothelial cell migration; • antifungal humoral response; • GO:0051637 defense response to Gram-positive bacterium; • antimicrobial humoral immune response mediated by antimicrobial peptide; • amylin receptor signaling pathway; • calcitonin gene-related peptide receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	796
	n/a
	ENSG00000110680
	n/a
	P06881
	n/a
	NM_001033952; NM_001033953; NM_001741; NM_001378949; NM_001378950
	n/a
	NP_001029125.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CALCA yw CALCA a elwir hefyd yn Calcitonin gene-related peptide 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CALCA.

CT
KC
PCT
CGRP
CALC1
CGRP1
CGRP-I

Llyfryddiaeth

"Calcitonin Gene-Related Peptide Induces HIV-1 Proteasomal Degradation in Mucosal Langerhans Cells. ". J Virol. 2017. PMID 28904199.
"Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients. ". J Orthop Surg Res. 2017. PMID 28431586.
"Procalcitonin Impairs Liver Cell Viability and Function In Vitro: A Potential New Mechanism of Liver Dysfunction and Failure during Sepsis?". Biomed Res Int. 2017. PMID 28255555.
"The Diagnostic Value of Procalcitonin Versus Other Biomarkers in Prediction of Bloodstream Infection. ". Clin Lab. 2017. PMID 28182347.
"Basal Serum Calcitonin, After Calcium Stimulation, and in the Needle Washout of Patients with Thyroid Nodules and Mild or Moderate Basal Hypercalcitoninemia.". Horm Metab Res. 2017. PMID 28166595.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CALCA - Cronfa NCBI

[1]

[2]