CASP2

CASP2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1PYO, 2P2C, 3R5J, 3R6G, 3R6L, 3R7B, 3R7N, 3R7S, 3RJM
Dynodwyr
Cyfenwau	CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, caspase 2
Dynodwyr allanol	OMIM: 600639 HomoloGene: 7254 GeneCards: CASP2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cysteine-type peptidase activity; • protein domain specific binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • enzyme binding; • hydrolase activity; • identical protein binding; • cysteine-type endopeptidase activity involved in apoptotic process; • cysteine-type endopeptidase activity; • cysteine-type endopeptidase activity involved in execution phase of apoptosis;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • mitocondria; • cnewyllyn cell;
Prosesau biolegol	• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • execution phase of apoptosis; • protein processing; • GO:0010260 heneiddio; • positive regulation of apoptotic signaling pathway; • luteolysis; • cellular response to mechanical stimulus; • positive regulation of neuron apoptotic process; • brain development; • intrinsic apoptotic signaling pathway in response to DNA damage; • extrinsic apoptotic signaling pathway in absence of ligand; • positive regulation of apoptotic process; • ectopic germ cell programmed cell death; • apoptotic signaling pathway; • neural retina development; • GO:0097285 apoptotic process; • regulation of apoptotic process; • proteolysis; • negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	835
	n/a
	ENSG00000106144
	n/a
	P42575
	n/a
	NM_032983; NM_001224; NM_032982; NM_032984
	n/a
	NP_001215; NP_116764; NP_116765
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CASP2 yw CASP2 a elwir hefyd yn Caspase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q34.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CASP2.

ICH1
NEDD2
CASP-2
NEDD-2
PPP1R57

Llyfryddiaeth

"Mechanism of caspase-2 activation upon DNA damage. ". Dokl Biochem Biophys. 2016. PMID 27193717.
"Caspase-2 regulates oncogene-induced senescence. ". Oncotarget. 2014. PMID 25114039.
"Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression. ". Future Oncol. 2013. PMID 23469978.
"Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike. ". J Biol Chem. 2012. PMID 22825847.
"Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice.". J Biol Chem. 2012. PMID 22396545.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CASP2 - Cronfa NCBI

[1]

[2]