CASP7

CASP7
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1F1J, 1GQF, 1I4O, 1I51, 1K86, 1K88, 1KMC, 1SHJ, 1SHL, 2QL5, 2QL7, 2QL9, 2QLB, 2QLF, 2QLJ, 3EDR, 3H1P, 3IBC, 3IBF, 3R5K, 4FDL, 4FEA, 4HQ0, 4HQR, 4JB8, 4JJ8, 4JR1, 4JR2, 4LSZ, 4ZVR, 4ZVQ, 4ZVO, 4ZVU, 4ZVT, 4ZVS, 4ZVP, 5IC6
Dynodwyr
Cyfenwau	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, Caspase 7
Dynodwyr allanol	OMIM: 601761 HomoloGene: 11168 GeneCards: CASP7
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cysteine-type peptidase activity; • cysteine-type endopeptidase activity; • GO:0001948, GO:0016582 protein binding; • hydrolase activity; • GO:0070122 peptidase activity; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity involved in apoptotic process;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cnewyllyn cell; • nucleoplasm;
Prosesau biolegol	• proteolysis; • cellular response to staurosporine; • execution phase of apoptosis; • GO:0097285 apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	840
	n/a
	ENSG00000165806
	n/a
	P55210
	n/a
NM_001227; NM_001267056; NM_001267057; NM_001267058; NM_033338;
	NM_033339; NM_033340; NM_001320911
	n/a
NP_001218; NP_001253985; NP_001253986; NP_001253987; NP_001307840;
	NP_203124; NP_203125; NP_203126
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CASP7 yw CASP7 a elwir hefyd yn Caspase 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CASP7.

MCH3
CMH-1
LICE2
CASP-7
ICE-LAP3

Llyfryddiaeth

"Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered Regions. ". Biochemistry. 2017. PMID 28863261.
"A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE Îµ4 allele carriers. ". BMC Genomics. 2016. PMID 27358062.
"CASP7 variants modify susceptibility to cervical cancer in Chinese women. ". Sci Rep. 2015. PMID 25784056.
"Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. ". PLoS One. 2013. PMID 24040159.
"Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment.". Chest. 2012. PMID 22441531.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CASP7 - Cronfa NCBI

[1]

[2]