CASP8

CASP8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7, 4PRZ, 4PS1, 4ZBW
Dynodwyr
Cyfenwau	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, caspase 8
Dynodwyr allanol	OMIM: 601763 HomoloGene: 7657 GeneCards: CASP8
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• death effector domain binding; • cysteine-type peptidase activity; • cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • scaffold protein binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • cysteine-type endopeptidase activity involved in apoptotic process; • cysteine-type endopeptidase activity; • hydrolase activity; • ubiquitin protein ligase binding; • GO:0070122 peptidase activity; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • death receptor binding; • tumor necrosis factor receptor binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• cell body; • cytosol; • CD95 death-inducing signaling complex; • ripoptosome; • nucleoplasm; • mitochondrial outer membrane; • death-inducing signaling complex; • membrane raft; • neuron projection; • Cytosgerbwd; • cytoplasm; • mitocondria; • cnewyllyn cell; • GO:0009327 protein-containing complex;
Prosesau biolegol	• regulation of apoptotic process; • response to estradiol; • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • GO:1904576 response to antibiotic; • regulation of tumor necrosis factor-mediated signaling pathway; • positive regulation of macrophage differentiation; • GO:1904579 cellular response to organic cyclic compound; • natural killer cell activation; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • TRAIL-activated apoptotic signaling pathway; • proteolysis; • macrophage differentiation; • TRIF-dependent toll-like receptor signaling pathway; • response to tumor necrosis factor; • B cell activation; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • cellular response to mechanical stimulus; • activation of cysteine-type endopeptidase activity; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • death-inducing signaling complex assembly; • positive regulation of proteolysis; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • apoptotic signaling pathway; • response to cold; • regulation of extrinsic apoptotic signaling pathway via death domain receptors; • GO:0022415 viral process; • response to ethanol; • response to cobalt ion; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • proteolysis involved in cellular protein catabolic process; • syncytiotrophoblast cell differentiation involved in labyrinthine layer development; • nucleotide-binding oligomerization domain containing signaling pathway; • T cell activation; • suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; • GO:0097285 apoptotic process; • extrinsic apoptotic signaling pathway; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • regulation of necroptotic process; • execution phase of apoptosis; • toll-like receptor 3 signaling pathway; • positive regulation of neuron death; • extrinsic apoptotic signaling pathway via death domain receptors; • positive regulation of interleukin-1 beta production;
	Sources:Amigo / QuickGO
Orthologau
	841
	n/a
	ENSG00000064012
	n/a
	Q14790
	n/a
NM_001080124; NM_001080125; NM_001228; NM_033355; NM_033356;
	NM_033357; NM_033358; NM_001372051
	n/a
NP_001073593; NP_001073594; NP_001219; NP_203519; NP_203520;
	NP_203522; NP_001358980
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CASP8 yw CASP8 a elwir hefyd yn Caspase-8 a Caspase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CASP8.

CAP4
MACH
MCH5
FLICE
ALPS2B
Casp-8

Llyfryddiaeth

"Q482H mutation of procaspase-8 in acute myeloid leukemia abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization. ". Biochem Biophys Res Commun. 2018. PMID 29191655.
"Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. ". PLoS One. 2017. PMID 28985224.
"DNA methylation-mediated caspase-8 downregulation is associated with anti-apoptotic activity and human malignant glioma grade. ". Int J Mol Med. 2017. PMID 28204824.
"Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line. ". Mol Cell Biochem. 2017. PMID 27868169.
"Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.". BMC Cancer. 2016. PMID 27507139.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CASP8 - Cronfa NCBI

[1]

[2]