CBFA2T3

CBFA2T3
Dynodwyr
Cyfenwau	CBFA2T3, ETO2, MTG16, MTGR2, ZMYND4, RUNX1T3, CBFA2/RUNX1 translocation partner 3, CBFA2/RUNX1 partner transcriptional co-repressor 3
Dynodwyr allanol	OMIM: 603870 HomoloGene: 74543 GeneCards: CBFA2T3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001948, GO:0016582 protein binding; • metal ion binding; • GO:0001106 transcription corepressor activity;
Cydrannau o'r gell	• Golgi membrane; • Golgi apparatus; • nucleolus; • bilen; • cnewyllyn cell; • nucleoplasm;
Prosesau biolegol	• regulation of aerobic respiration; • cell differentiation; • cell population proliferation; • negative regulation of glycolytic process; • response to hypoxia; • granulocyte differentiation; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • transcription, DNA-templated; • negative regulation of cell population proliferation; • GO:0045996 negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologau
	863
	n/a
	ENSG00000129993
	n/a
	O75081
	n/a
	NM_005187; NM_175931
	n/a
	NP_005178; NP_787127
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBFA2T3 yw CBFA2T3 a elwir hefyd yn Protein CBFA2T3 a CBFA2/RUNX1 translocation partner 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q24.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBFA2T3.

ETO2
MTG16
MTGR2
ZMYND4
RUNX1T3

Llyfryddiaeth

"CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. ". Cancer Res. 2002. PMID 12183414.
"A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. ". Leuk Lymphoma. 2002. PMID 11999578.
"The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. ". Blood. 1998. PMID 9596646.
"ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia. ". Cancer Cell. 2017. PMID 28292442.
"Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene.". Turk J Haematol. 2016. PMID 27094503.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CBFA2T3 - Cronfa NCBI

[1]

[2]