CCKBR

CCKBR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1L4T
Dynodwyr
Cyfenwau	CCKBR, CCK-B, CCK2R, GASR, cholecystokinin B receptor
Dynodwyr allanol	OMIM: 118445 HomoloGene: 7258 GeneCards: CCKBR
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• G protein-coupled receptor activity; • signal transducer activity; • 1-phosphatidylinositol-3-kinase regulator activity; • GO:0001948, GO:0016582 protein binding; • type B gastrin/cholecystokinin receptor binding; • gastrin receptor activity; • cholecystokinin receptor activity; • peptide hormone binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen;
Prosesau biolegol	• gastric acid secretion; • positive regulation of cytosolic calcium ion concentration; • cell surface receptor signaling pathway; • positive regulation of cell population proliferation; • cell population proliferation; • digestive tract development; • GO:0072468 signal transduction; • gland development; • regulation of phosphatidylinositol 3-kinase activity; • G protein-coupled receptor signaling pathway; • phospholipase C-activating G protein-coupled receptor signaling pathway; • cholecystokinin signaling pathway; • pH reduction;
	Sources:Amigo / QuickGO
Orthologau
	887
	n/a
	ENSG00000110148
	n/a
	P32239
	n/a
	NM_176875; NM_001318029; NM_001363552
	n/a
	NP_001304958; NP_795344; NP_001350481
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCKBR yw CCKBR a elwir hefyd yn Cholecystokinin B receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.4.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCKBR.

GASR
CCK-B
CCK2R

Llyfryddiaeth

"Z-360 Suppresses Tumor Growth in MIA PaCa-2-bearing Mice viaInhibition of Gastrin-induced Anti-Apoptotic Effects. ". Anticancer Res. 2017. PMID 28739697.
"Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue. ". Oncotarget. 2016. PMID 26910279.
"A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. ". Pancreas. 2016. PMID 26646278.
"Immunohistochemical examination of cholecystokinin and gastrin receptors (CCK-2/gastrin-R) expression in normal and exocrine cancerous human pancreatic tissues. ". Pancreatology. 2015. PMID 26520651.
"Distribution of cholecystokinin-B receptor genotype between patients with pancreatic cancer and controls and its impact on survival.". Pancreas. 2015. PMID 25469546.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CCKBR - Cronfa NCBI

[1]

[2]