CCL11

CCL11
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EOT, 2EOT, 2MPM
Dynodwyr
Cyfenwau	CCL11, SCYA11, C-C motif chemokine ligand 11
Dynodwyr allanol	OMIM: 601156 HomoloGene: 7929 GeneCards: CCL11
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • GO:0001948, GO:0016582 protein binding; • chemokine activity; • CCR3 chemokine receptor binding; • protein dimerization activity; • receptor ligand activity; • CCR chemokine receptor binding;
Cydrannau o'r gell	• extracellular region; • extracellular space; • intracellular anatomical structure;
Prosesau biolegol	• G protein-coupled receptor signaling pathway; • positive regulation of endothelial cell proliferation; • positive regulation of actin filament polymerization; • response to interleukin-4; • branching involved in mammary gland duct morphogenesis; • monocyte chemotaxis; • actin filament organization; • positive regulation of cell migration; • chemokine-mediated signaling pathway; • response to interleukin-13; • cellular response to tumor necrosis factor; • response to virus; • cellular calcium ion homeostasis; • mast cell chemotaxis; • neutrophil chemotaxis; • positive regulation of angiogenesis; • mammary duct terminal end bud growth; • chemotaxis; • protein phosphorylation; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • cell adhesion; • cytoskeleton organization; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • response to radiation; • inflammatory response; • chronic inflammatory response; • GO:0072468 signal transduction; • eosinophil chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologau
	6356
	n/a
	ENSG00000172156
	n/a
	P51671
	n/a
	NM_002986
	n/a
	NP_002977
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCL11 yw CCL11 a elwir hefyd yn C-C motif chemokine ligand 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCL11.

SCYA11

Llyfryddiaeth

"CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. ". PLoS One. 2017. PMID 28950005.
"Eotaxin Augments Calcification in Vascular Smooth Muscle Cells. ". J Cell Biochem. 2017. PMID 27681294.
"The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. ". Dis Markers. 2015. PMID 26491210.
"Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease. ". Mol Psychiatry. 2015. PMID 26324103.
"Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence?". Prostate. 2015. PMID 26306920.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CCL11 - Cronfa NCBI

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[2]