CCL3

CCL3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Dynodwyr
Cyfenwau	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
Dynodwyr allanol	OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein kinase activity; • cytokine activity; • CCR5 chemokine receptor binding; • chemokine activity; • CCR1 chemokine receptor binding; • kinase activity; • phospholipase activator activity; • calcium-dependent protein kinase C activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • chemoattractant activity; • CCR chemokine receptor binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • intracellular anatomical structure; • extracellular region; • extracellular space;
Prosesau biolegol	• G protein-coupled receptor signaling pathway; • signaling; • negative regulation of bone mineralization; • positive regulation of protein kinase B signaling; • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • response to cholesterol; • positive regulation of calcium-mediated signaling; • regulation of sensory perception of pain; • protein kinase B signaling; • monocyte chemotaxis; • negative regulation of osteoclast differentiation; • astrocyte cell migration; • positive regulation of cell migration; • positive regulation of natural killer cell chemotaxis; • chemokine-mediated signaling pathway; • T cell chemotaxis; • cell-cell signaling; • cellular response to tumor necrosis factor; • eosinophil chemotaxis; • GO:1904579 cellular response to organic cyclic compound; • cellular calcium ion homeostasis; • negative regulation of gene expression; • neutrophil chemotaxis; • cell activation; • MAPK cascade; • chemotaxis; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • positive regulation of neuron apoptotic process; • positive regulation of calcium ion import; • macrophage chemotaxis; • GO:1901313 positive regulation of gene expression; • cytoskeleton organization; • osteoblast differentiation; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • positive regulation of tumor necrosis factor production; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • inflammatory response; • granulocyte chemotaxis; • response to toxic substance; • eosinophil degranulation; • lipopolysaccharide-mediated signaling pathway; • calcium ion transport; • calcium-mediated signaling; • exocytosis; • positive regulation of calcium ion transport; • positive chemotaxis; • positive regulation of inflammatory response; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • regulation of behavior; • positive regulation of microglial cell activation; • positive regulation of microglial cell migration;
	Sources:Amigo / QuickGO
Orthologau
	6348
	n/a
	ENSG00000278567; ENSG00000277632; ENSG00000274221
	n/a
	P10147
	n/a
	NM_002983
	n/a
	NP_002974
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCL3 yw CCL3 a elwir hefyd yn C-C motif chemokine ligand 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCL3.

MIP1A
SCYA3
G0S19-1
LD78ALPHA
MIP-1-alpha

Llyfryddiaeth

"Macrophage inflammatory protein 1 alpha (MIP-1α) may be associated with poor outcome in patients with extranodal NK/T-cell lymphoma. ". Hematol Oncol. 2017. PMID 26928433.
"CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells. ". Oncotarget. 2016. PMID 26713602.
"MIP-1α level in nasopharyngeal aspirates at the first wheezing episode predicts recurrent wheezing. ". J Allergy Clin Immunol. 2016. PMID 26494023.
"CCL3 chemokine expression by chronic lymphocytic leukemia cells orchestrates the composition of the microenvironment in lymph node infiltrates. ". Leuk Lymphoma. 2016. PMID 26458057.
"Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study.". Cancer Sci. 2015. PMID 25940505.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CCL3 - Cronfa NCBI

[1]

[2]