CCL4

CCL4L1
Dynodwyr
Cyfenwau	CCL4L1, AT744.2, CCL4L, LAG-1, LAG1, SCYA4L, SCYA4L1, MIP-1-beta, SCYA4L2, C-C motif chemokine ligand 4 like 1
Dynodwyr allanol	OMIM: 603782 GeneCards: CCL4L1
Ontoleg y genyn
Gweithrediad moleciwlaidd	• chemokine activity; • cytokine activity; • GO:0001948, GO:0016582 protein binding; • CCR chemokine receptor binding;
Cydrannau o'r gell	• extracellular region; • extracellular space;
Prosesau biolegol	• lymphocyte chemotaxis; • chemokine-mediated signaling pathway; • cellular response to tumor necrosis factor; • G protein-coupled receptor signaling pathway; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • chemotaxis; • inflammatory response; • cellular response to interleukin-1; • monocyte chemotaxis; • neutrophil chemotaxis; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of ERK1 and ERK2 cascade; • cellular response to interferon-gamma; • regulation of signaling receptor activity; • eosinophil chemotaxis;
	Sources:Amigo / QuickGO
Orthologau
	388372
	n/a
	n/a
	n/a
	Q8NHW4
	n/a
	NM_207007
	n/a
	NP_996890
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCL4 yw CCL4 a elwir hefyd yn C-C motif chemokine ligand 4 like 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCL4.

ACT2
G-26
HC21
LAG1
LAG-1
MIP1B
SCYA2
SCYA4
MIP1B1
AT744.1
MIP-1-beta

Llyfryddiaeth

"High MIP-1β Levels in Plasma Predict Long-Term Immunological Nonresponse to Suppressive Antiretroviral Therapy in HIV Infection. ". J Acquir Immune Defic Syndr. 2015. PMID 26115437.
"MicroRNA-125b modulates inflammatory chemokine CCL4 expression in immune cells and its reduction causes CCL4 increase with age. ". Aging Cell. 2015. PMID 25620312.
"Increased expression of CCL4/MIP-1β in CD8+ cells and CD4+ cells in sarcoidosis. ". Int J Immunopathol Pharmacol. 2014. PMID 25004830.
"Procalcitonin and macrophage inflammatory protein-1 beta (MIP-1β) in serum and peritoneal fluid of patients with decompensated cirrhosis and spontaneous bacterial peritonitis. ". Adv Med Sci. 2014. PMID 24797975.
"The association between CCL2 polymorphisms and drug-resistant epilepsy in Chinese children.". Epileptic Disord. 2013. PMID 23996681.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CCL4 - Cronfa NCBI

[1]

[2]