CCL5

CCL5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Dynodwyr
Cyfenwau	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
Dynodwyr allanol	OMIM: 187011 HomoloGene: 2244 GeneCards: CCL5
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• CCR5 chemokine receptor binding; • receptor signaling protein tyrosine kinase activator activity; • chemokine activity; • protein self-association; • CCR4 chemokine receptor binding; • phosphatidylinositol phospholipase C activity; • protein kinase activity; • cytokine activity; • CCR1 chemokine receptor binding; • phospholipase activator activity; • chemokine receptor binding; • protein homodimerization activity; • chemokine receptor antagonist activity; • GO:0001948, GO:0016582 protein binding; • chemoattractant activity; • identical protein binding; • CCR chemokine receptor binding;
Cydrannau o'r gell	• cytoplasm; • extracellular region; • extracellular space;
Prosesau biolegol	• leukocyte cell-cell adhesion; • positive regulation of cell-cell adhesion mediated by integrin; • regulation of T cell activation; • positive regulation of smooth muscle cell migration; • activation of phospholipase D activity; • negative regulation of viral genome replication; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of innate immune response; • cellular response to interferon-gamma; • positive regulation of macrophage chemotaxis; • calcium ion transport; • exocytosis; • positive regulation of calcium ion transport; • response to cytokine; • regulation of insulin secretion; • chemokine-mediated signaling pathway; • positive regulation of cellular biosynthetic process; • response to virus; • positive regulation of monocyte chemotaxis; • cellular response to fibroblast growth factor stimulus; • neutrophil chemotaxis; • response to tumor necrosis factor; • negative regulation of T cell apoptotic process; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • negative regulation of macrophage apoptotic process; • positive regulation of T cell proliferation; • positive regulation of phosphorylation; • inflammatory response; • positive regulation of translational initiation; • response to toxic substance; • positive regulation of epithelial cell proliferation; • positive regulation of tyrosine phosphorylation of STAT protein; • GO:1904579 cellular response to organic cyclic compound; • cellular calcium ion homeostasis; • protein tetramerization; • chemotaxis; • positive regulation of homotypic cell-cell adhesion; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of viral genome replication; • positive regulation of receptor signaling pathway via JAK-STAT; • lipopolysaccharide-mediated signaling pathway; • positive regulation of T cell migration; • regulation of chronic inflammatory response; • positive regulation of smooth muscle cell proliferation; • neutrophil activation; • protein kinase B signaling; • positive regulation of cell migration; • positive regulation of natural killer cell chemotaxis; • cell-cell signaling; • eosinophil chemotaxis; • dendritic cell chemotaxis; • MAPK cascade; • macrophage chemotaxis; • positive regulation of T cell chemotaxis; • regulation of neuron death; • positive regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of G protein-coupled receptor signaling pathway; • positive regulation of T cell apoptotic process; • positive regulation of cell adhesion; • negative regulation of chemokine-mediated signaling pathway; • monocyte chemotaxis; • positive chemotaxis; • positive regulation of protein tyrosine kinase activity; • cellular response to tumor necrosis factor; • positive regulation of activation of Janus kinase activity; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • lymphocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologau
	6352
	n/a
	ENSG00000271503; ENSG00000274233
	n/a
	P13501
	n/a
	NM_002985; NM_001278736
	n/a
	NP_001265665; NP_002976
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCL5 yw CCL5 a elwir hefyd yn C-C motif chemokine ligand 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCL5.

SISd
eoCP
SCYA5
RANTES
TCP228
D17S136E
SIS-delta

Llyfryddiaeth

"Impact of Rantes from jawbone on Chronic Fatigue Syndrome. ". J Biol Regul Homeost Agents. 2017. PMID 28685531.
"RANTES levels in peripheral blood, CSF and contused brain tissue as a marker for outcome in traumatic brain injury (TBI) patients. ". BMC Res Notes. 2017. PMID 28340601.
"Chemokine Ligand 5 (CCL5) Derived from Endothelial Colony-Forming Cells (ECFCs) Mediates Recruitment of Smooth Muscle Progenitor Cells (SPCs) toward Critical Vascular Locations in Moyamoya Disease. ". PLoS One. 2017. PMID 28072843.
"RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population. ". Dis Markers. 2016. PMID 27821902.
"CCL5 rs2107538 Polymorphism Increased the Risk of Tuberculosis in a Sample of Iranian Population.". Prague Med Rep. 2016. PMID 27668525.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CCL5 - Cronfa NCBI

[1]

[2]