CD40

CD40
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI
Dynodwyr
Cyfenwau	CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule
Dynodwyr allanol	OMIM: 109535 HomoloGene: 954 GeneCards: CD40
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0003823, GO:0051635 antigen binding; • signal transducer activity; • GO:0001948, GO:0016582 protein binding; • tumor necrosis factor-activated receptor activity; • enzyme binding; • ubiquitin protein ligase binding; • protein domain specific binding; • signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • intracellular membrane-bounded organelle; • bilen; • Cellbilen; • integral component of plasma membrane; • extracellular region; • cell surface; • CD40 receptor complex; • extracellular exosome; • external side of plasma membrane; • extracellular space; • soma; • varicosity;
Prosesau biolegol	• positive regulation of protein phosphorylation; • positive regulation of MAP kinase activity; • positive regulation of interleukin-12 production; • protein kinase B signaling; • positive regulation of protein kinase C signaling; • immune system process; • cellular calcium ion homeostasis; • tumor necrosis factor-mediated signaling pathway; • immune response-regulating cell surface receptor signaling pathway; • platelet activation; • multicellular organism development; • B cell activation; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • response to lipopolysaccharide; • B cell proliferation; • cellular response to mechanical stimulus; • positive regulation of endothelial cell apoptotic process; • regulation of cell population proliferation; • positive regulation of B cell proliferation; • positive regulation of NF-kappaB transcription factor activity; • defense response to virus; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • regulation of immune response; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • apoptotic signaling pathway; • positive regulation of isotype switching to IgG isotypes; • cellular response to lipopolysaccharide; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • defense response to protozoan; • response to bacterium; • response to nutrient levels; • response to cobalamin; • response to interferon-gamma; • cellular response to erythropoietin; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • response to peptide; • inflammatory response; • positive regulation of tyrosine phosphorylation of STAT protein; • positive regulation of blood vessel endothelial cell migration; • positive regulation of angiogenesis; • GO:0034622 protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologau
	958
	n/a
	ENSG00000101017
	n/a
	P25942
	n/a
NM_001250; NM_001302753; NM_152854; NM_001322421; NM_001322422;
	NM_001362758
	n/a
NP_001241; NP_001289682; NP_001309350; NP_001309351; NP_690593;
	NP_001349687
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD40 yw CD40 a elwir hefyd yn CD40 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD40.

p50
Bp50
CDW40
TNFRSF5

Llyfryddiaeth

"Single nucleotide polymorphisms in the CD40 gene associate with the disease susceptibility and severity in knee osteoarthritis in the Chinese Han population: a case-control study. ". BMC Musculoskelet Disord. 2017. PMID 28320398.
"A High Level of Soluble CD40L Is Associated with P. aeruginosa Infection in Patients with Cystic Fibrosis. ". PLoS One. 2016. PMID 28030642.
"Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation. ". Circ Res. 2016. PMID 27992360.
"Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. ". Arch Oral Biol. 2017. PMID 27875792.
"CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico.". Genet Mol Res. 2016. PMID 27813548.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CD40 - Cronfa NCBI

[1]

[2]